Search
Proteintech
MEK4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
17340-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEK4 Fusion Protein Ag11376 (50-399 aa encoded by BC036032)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NPPFKSTAR FTLNPNPTGV QNPHIERLRT HSIESSGKLK ISPEQHWDFT AEDLKDLGEI GRGAYGSVNK MVHKPSGQIM AVKRIRSTVD EKEQKQLLMD LDVVMRSSDC PYIVQFYGAL FREGDCWICM ELMSTSFDKF YKYVYSVLDD VIPEEILGKI TLATVKALNH LKENLKIIHR DIKPSNILLD RSGNIKLCDF GISGQLVDSI AKTRDAGCRP YMAPERIDPS ASRQGYDVRS DVWSLGITLY ELATGRFPYP KWNSVFDQLT QVVKGDPPQL SNSEEREFSP SFINFVNLCL TKDESKRPKY KELLKHPFIL MYEERAVEVA CYVCKILDQM PATPSSPMYV D (50-399 aa encoded by BC036032)
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-JUN N-terminal kinase kinase 1; c-Jun NH2-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; MAP kinase kinase 4; MAP2K4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; mitogen activated protein kinase kinase 4, variant 1; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SEK1; Stress-activated protein kinase kinase 1; unnamed protein product
Gene Aliases: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985, (Mouse) P47809
Entrez Gene ID: (Human) 6416, (Mouse) 26398
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
JUN kinase kinase activity
kinase activity
transferase activity
binding, bridging
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase kinase binding
non-receptor serine/threonine protein kinase
MAPK cascade
apoptotic process
signal transduction
JNK cascade
response to wounding
cellular response to stress
smooth muscle cell apoptotic process
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
cellular senescence
negative regulation of motor neuron apoptotic process
positive regulation of protein phosphorylation
protein phosphorylation
activation of JUN kinase activity
phosphorylation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of DNA replication
positive regulation of nitric-oxide synthase biosynthetic process
cell growth involved in cardiac muscle cell development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support