MAP2K5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. It specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation.
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Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; MEK 5; mitogen activated protein kinase kinase 5
Gene Aliases: AI324775; AI428457; HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5