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Product Details
15758-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEK5 Fusion Protein Ag8351 (96-448 aa encoded by BC008838)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GQLIEPLQI FPRACKPPGE RNIHGLKVNT RAGPSQHSSP AVSDSLPSNS LKKSSAELKK ILANGQMNEQ DIRYRDTLGH GNGGTVYKAY HVPSGKILAV KVILLDITLE LQKQIMSELE ILYKCDSSYI IGFYGAFFVE NRISICTEFM DGGSLDVYRK MPEHVLGRIA VAVVKGLTYL WSLKILHRDV KPSNMLVNTR GQVKLCDFGV STQLVNSIAK TYVGTNAYMA PERISGEQYG IHSDVWSLGI SFMELALGRF PYPQIQKNQG SLMPLQLLQC IVDEDSPVLP VGEFSEPFVH FITQCMRKQP KERPAPEELM GHPFIVQFND GNAAVVSMWV CRALEERRSQ QGPP (96-448 aa encoded by BC008838)
Target Information
MAP2K5 (MEK5) serine/threonine kinase (mitogen-activated protein kinase 5) or MEK5 is a dual specificity protein kinase that belongs to the MAP kinase family which specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect the risk of developing colorectal cancer (CRC).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; MEK 5; mitogen activated protein kinase kinase 5
Gene Aliases: AI324775; AI428457; HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5
UniProt ID: (Human) Q13163, (Mouse) Q9WVS7, (Rat) Q62862
Entrez Gene ID: (Human) 5607, (Mouse) 23938, (Rat) 29568
protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein serine/threonine kinase activity
MAP kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
signal transduction
heart development
peptidyl-tyrosine phosphorylation
positive regulation of cell growth
negative regulation of NF-kappaB transcription factor activity
negative regulation of heterotypic cell-cell adhesion
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein metabolic process
negative regulation of response to cytokine stimulus
ERK5 cascade
cellular response to growth factor stimulus
cellular response to laminar fluid shear stress
negative regulation of cell migration involved in sprouting angiogenesis
negative regulation of chemokine (C-X-C motif) ligand 2 production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
MAPK cascade
protein phosphorylation
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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