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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
MEK5 Fusion Protein Ag8351 (96-448 aa encoded by BC008838) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.13 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: GQLIEPLQI FPRACKPPGE RNIHGLKVNT RAGPSQHSSP AVSDSLPSNS LKKSSAELKK ILANGQMNEQ DIRYRDTLGH GNGGTVYKAY HVPSGKILAV KVILLDITLE LQKQIMSELE ILYKCDSSYI IGFYGAFFVE NRISICTEFM DGGSLDVYRK MPEHVLGRIA VAVVKGLTYL WSLKILHRDV KPSNMLVNTR GQVKLCDFGV STQLVNSIAK TYVGTNAYMA PERISGEQYG IHSDVWSLGI SFMELALGRF PYPQIQKNQG SLMPLQLLQC IVDEDSPVLP VGEFSEPFVH FITQCMRKQP KERPAPEELM GHPFIVQFND GNAAVVSMWV CRALEERRSQ QGPP (96-448 aa encoded by BC008838)
MAP2K5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. It specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; MEK 5; mitogen activated protein kinase kinase 5
Gene Aliases: AI324775; AI428457; HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5
UniProt ID: (Human) Q13163, (Mouse) Q9WVS7, (Rat) Q62863
Entrez Gene ID: (Human) 5607, (Mouse) 23938, (Rat) 29568
Molecular Function:
non-receptor serine/threonine protein kinase
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