Immunogen sequence: IFPRACKPPG ERNIHGLKVN TRAGPSQHSS PAVSDSLPSN SLKKSSAELK KILANGQMNE QDIRYRDTLG HGNG
The mitogen/extracellular-signal-regulated kinase kinase 5/extracellular signal-regulated kinase-5 (MEK5/ERK5) pathway has been implicated in the regulation of cellular proliferation. MEKs activate their downstream MAPK by phosphorylation of threonine and tyrosine in the T- X- Y motif. MEK5 is the upsteam BMK1 kinase and exists as naturally occurring splice variants, MEK5alpha and MEK5 beta. The full length MEK5 (MEK5alpha) is 89 amino acids longer than MEk5 beta at the N terminus MEK5 can autophosphorylated on Ser/Thr and Tyr residues. Studies show that dual phosphorylation sites at Ser-311 and Thr- 315 are very important for cell proliferation. MEK5/MAPKK5 is expressed in many adult tissues and are abundant in heart and skeletal muscle. MEK5 is also a key signaling molecule associated with prostate carcinogenesis. As the MEK5/ERK5 interaction is highly specific, it represents a potential target of therapy.
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Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; MEK 5; MEK5; PRKMK5
Gene Aliases: HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5
UniProt ID: (Human) Q13163
Entrez Gene ID: (Human) 5607