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Invitrogen
MEK6 Polyclonal Antibody
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FIGURE: 1 / 5
MEK6 Antibody (PA5-17416) in ICC/IF
Immunofluorescence analysis of MEK6 was performed using 70% confluent log phase HeLa and HCT 116 cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with MEK6 Polyclonal Antibody (Product # PA5-17416) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Secondary Antibody, Alexa Fluor® 488 (Pro... View More
Product Details
PA5-17416
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the sequence of human MKK6
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MKK6 (MEK6, MAP2K6) is a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. Tissue specificity: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Colorectal Cancer Metastasis-Suppressed LncRNA; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MAPKK3; MEK 3; MEK 6; MEK3; mitogen activated protein kinase kinase 6; MKK3; PRKMK3; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK-2; SAPKK2; SAPKK3; Stress-activated protein kinase kinase 3; unnamed protein product
Gene Aliases: CRCMSL; MAP2K6; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3; SKK3
UniProt ID: (Human) P52564, (Mouse) P70236
Entrez Gene ID: (Human) 5608, (Mouse) 26399, (Rat) 114495
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
identical protein binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
receptor signaling protein serine/threonine kinase activity
non-receptor serine/threonine protein kinase
MAPK cascade
osteoblast differentiation
apoptotic process
signal transduction
stress-activated protein kinase signaling cascade
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
p38MAPK cascade
signal transduction in response to DNA damage
positive regulation of MAPK cascade
stress-activated MAPK cascade
protein maturation
regulation of cell cycle
cardiac muscle contraction
bone development
pyroptosis
cellular response to UV-B
cellular senescence
negative regulation of cold-induced thermogenesis
regulation of signal transduction by p53 class mediator
regulation of intracellular signal transduction
NLRP1 inflammasome complex assembly
activation of MAPK activity
positive regulation of protein phosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
regulation of mitotic cell cycle
regulation of signal transduction
phosphorylation
positive regulation of prostaglandin secretion
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of nitric-oxide synthase biosynthetic process
response to ischemia
ovulation cycle process
intracellular signal transduction
response to drug
cellular response to sorbitol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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