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Invitrogen
MEK7 Polyclonal Antibody
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Product Details
PA5-96087
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human MEK7 (NP_6601861)
Conjugate
Form
Liquid
Concentration
2.27 mg/mL
Amount
227 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, HL-60, Jurkat, PC-3, K-562, Mouse liver, Mouse testis, Mouse brain; Cellular Location: Cytoplasm, Nucleus
Immunogen sequence: MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES SPQHPTPPAR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL ENLGEMGSGT CGQVWKMRFR KTGHVIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI HRDVKPSNIL
Target Information
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a new family member of MAP kinase kinases; c-Jun N-terminal kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; JN; JNK kinase 2; JNK-activating kinase 2; JNKK 2; MAP kinase kinase 7; MAP2K4; map2k7; map2k7 {ECO:0000312|EMBL:AAX61178.1}; MAPK/ERK kinase 4; MAPK/ERK kinase 7; MAPKK 4; MAPKK 7; MEK 4; MEK 7; mitogen activated protein kinase kinase 7; protein kinase; protein kinase homolog; protein kinase, mitogen activated, kinase 7; SAPK kinase 1; SAPK kinase 4; SAPK/ERK kinase 1; SAPKK-1; SAPKK1; SEK1; Stress-activated protein kinase kinase 4; unnamed protein product
Gene Aliases: JNKK; 2; 5930412N11Rik; JNKK 2; JNKK2; MAP2K7; MAPKK 7; MAPKK7; MEK; MEK 7; MEK7; MKK7; PRKMK7; SAPKK-4; SAPKK4; sek2; SKK4
UniProt ID: (Human) O14733, (Rat) Q4KSH7, (Mouse) Q8CE90
Entrez Gene ID: (Human) 5609, (Rat) 363855, (Mouse) 26400
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
JUN kinase kinase activity
kinase activity
transferase activity
enzyme binding
protein kinase binding
protein phosphatase binding
metal ion binding
protein serine kinase activity
molecular function activator activity
protein C-terminus binding
mitogen-activated protein kinase kinase kinase binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
apoptotic process
response to osmotic stress
signal transduction
JNK cascade
response to heat
response to UV
response to wounding
stress-activated protein kinase signaling cascade
positive regulation of telomere maintenance
response to tumor necrosis factor
Fc-epsilon receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of transcription, DNA-templated
positive regulation of JNK cascade
stress-activated MAPK cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular senescence
regulation of motor neuron apoptotic process
positive regulation of protein phosphorylation
protein phosphorylation
activation of JUN kinase activity
peptidyl-tyrosine phosphorylation
positive regulation of neuron apoptotic process
cellular response to sorbitol
MAPK cascade
response to stress
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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