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Invitrogen

MEKK1 Polyclonal Antibody

View all (15) MEKK1 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-109933

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 -

Immunohistochemistry (Paraffin) (IHC (P))

 1:50-1:100 -

Immunocytochemistry (ICC/IF)

 1:50-1:100 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1400 to the C-terminus of human MAP3K1 (NP_005912.1).
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 1.53 mg/mL

Purification

 Affinity Chromatography

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.01% thimerosal

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2855344

Product Specific Information

Sequence of this protein is as follows: TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA LIFKIASATT APSIPSHLSP GLRDVALRCL ELQPQDRPPS RELLKHPVFR TTW

Target Information

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK1 can phosphorylate and activate MAPKK 1 and MAPKK 2 (MEK1/MEK2) which leads to phosphorylation of MAP kinases. It is also a highly efficient activator of the JNK cascade. The protein contains a putative 1 RING-type zinc finger and 1 SWIM-type zinc finger.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Gene Aliases: MAP3K1; MAPKKK1; MEKK; MEKK 1; MEKK1; SRXY6

UniProt ID: (Human) Q13233, (Rat) Q62925

Entrez Gene ID: (Human) 4214, (Mouse) 26401, (Rat) 116667

Molecular Function: non-receptor serine/threonine protein kinase

Function(s)
MAPK cascade activation of MAPKK activity MyD88-dependent toll-like receptor signaling pathway protein phosphorylation apoptotic process Fc-epsilon receptor signaling pathway cellular response to mechanical stimulus epithelial cell morphogenesis transforming growth factor beta receptor signaling pathway JNK cascade activation of JNKK activity activation of JUN kinase activity regulation of mitotic cell cycle apoptotic mitochondrial changes phosphorylation protein ubiquitination regulation of cell migration positive regulation of actin filament polymerization wound healing regulation of apoptotic process camera-type eye development eyelid development in camera-type eye protein polyubiquitination response to osmotic stress peptidyl-serine phosphorylation negative regulation of actin filament bundle assembly protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of JUN kinase activity positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation positive regulation of viral transcription protein oligomerization
Process(es)
protein kinase activity protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase kinase activity protein binding ATP binding zinc ion binding protein kinase binding nucleotide binding JUN kinase kinase kinase activity ubiquitin-protein transferase activity JUN kinase binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups mitogen-activated protein kinase kinase binding sphingolipid binding metal ion binding mitogen-activated protein kinase binding JUN kinase kinase activity
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