PA5-29322 targets MEKK3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-29322 immunogen is recombinant fragment corresponding to a region within amino acids 210 and 488 of Human MEKK3.
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This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
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Protein Aliases: MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEK kinase 3; MEKK 3; MEKK3; Mitogen-activated protein kinase kinase kinase 3
Gene Aliases: MAP3K3; MAPKKK3; MEKK3
UniProt ID: (Human) Q8N3I9
Entrez Gene ID: (Human) 4215