The synthetic peptide sequence is 11-25aa, MKDLVALQMSRRTRL
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also called MAP kinase kinase kinases) phosphorylate and activate the MAP kinases, including ERK, JNK and p38. The MEK kinases characterized to date include Raf-1, Raf-B, MOS, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4 and ASK 1 (also designated MEK kinase-5). MEK kinase-1 has been shown to phosphorylate MEK-1 via a Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK pathway. ASK1 activates both MEK-4 and MEK-3/MEK-6 pathways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Map3k3; MAPK/ERK kinase kinase 3; MEK kinase 3; MEKK 3; Mekk3; mitogen activated protein kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase 3
Gene Aliases: AW548911; Map3k3; MAPKKK3; Mekk3; mKIAA4031
UniProt ID: (Mouse) Q61084