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Proteintech
MEPCE Polyclonal Antibody
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Product Details
11526-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEPCE Fusion Protein Ag2092 (369-689 aa encoded by BC018935)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSKSEAGAR GGGQGSKEKG RGSWGGRHHH HHPLPAAGFK KQQRKFQYGN YCKYYGYRNP SCEDGRLRVL KPEWFRGRDV LDLGCNVGHL TLSIACKWGP SRMVGLDIDS RLIHSARQNI RHYLSEELRL PPQTLEGDPG AEGEEGTTTV RKRSCFPASL TASRGPIAAP QVPLDGADTS VFPNNVVFVT GNYVLDRDDL VEAQTPEYDV VLCLSLTKWV HLNWGDEGLK RMFRRIYRHL RPGGILVLEP QPWSSYGKRK TLTETIYKNY YRIQLKPEQF SSYLTSPDVG FSSYELVATP HNTSKGFQRP VYLFHKARSP SH (369-689 aa encoded by BC018935)
Target Information
S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 7SK snRNA methylphosphate capping enzyme; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3, homolog; FLJ20257; MePCE; unnamed protein product
Gene Aliases: BCDIN3; MEPCE
UniProt ID: (Human) Q7L2J0
Entrez Gene ID: (Human) 56257
negative regulation of transcription from RNA polymerase II promoter
RNA methylation
snRNA metabolic process
methylation
snRNA modification
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of protein localization to Cajal body
positive regulation of snRNA transcription by RNA polymerase II
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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