S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). [UniProt]
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Protein Aliases: 7SK snRNA methylphosphate capping enzyme; bcdin3; Bicoid-interacting protein 3 homolog; Bin3 homolog; bin3, bicoid-interacting 3; bin3, bicoid-interacting 3, homolog; FLJ20257; MePCE
Gene Aliases: BCDIN3; Bipl1; D5Wsu46e; fc59f06; MEPCE; si:ch211-283h6.1; wu:fc59f06; zBCDIN3