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Proteintech
MERTK Polyclonal Antibody
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Product Details
27900-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MERTK fusion protein Ag27540
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ELYEIMYSCW RTDPLDRPTF SVLRLQLEKL LESLPDVRNQ ADVIYVNTQL LESSEGLAQG STLAPLDLNI DPDSIIASCT PRAAISVVTA EVHDSKPHEG RYILNGGSEE WEDLTSAPSA AVTAEKNSVL PGERLVRNGV SWSHSSMLPL GSSLPDELLF ADDSSEGSEV LM
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-mer proto-oncogene tyrosine kinase; MER receptor tyrosine kinase; MGC133349; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyrosine-protein kinase Mer
Gene Aliases: c-Eyk; c-mer; Eyk; MER; MERTK; nmf12; Nyk; rdy; RP38; Tyro12
UniProt ID: (Human) Q12866, (Mouse) Q60805, (Rat) P57097
Entrez Gene ID: (Human) 10461, (Mouse) 17289, (Rat) 65037
natural killer cell differentiation
protein phosphorylation
phagocytosis
cell surface receptor signaling pathway
cell-cell signaling
spermatogenesis
peptidyl-tyrosine phosphorylation
platelet activation
secretion by cell
substrate adhesion-dependent cell spreading
apoptotic cell clearance
protein kinase B signaling
positive regulation of phagocytosis
leukocyte migration
negative regulation of lymphocyte activation
retina development in camera-type eye
vagina development
negative regulation of leukocyte apoptotic process
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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