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Fabgennix
MERTK Polyclonal Antibody
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FIGURE: 1 / 1
MERTK Antibody (MKT-112AP) in WB
WB of MERTK from Long Evans (LE) and RCS (MERTK-deficient) rat testis. Lane 1: LE testis extracts immunoprecipitated with MKT-101AP. Lane 2: LE testis extracts immunoprecipitated with MKT-121AP. Lane 3: RCS testis extract blotted with MKT-121AP. Lane 4: Immunodepleted sample of Lane 2 with P-MKT120 and blotted with MKT-121AP. Apparent MW of rat MERTK is 174 kDa +/- 5 kDa.
Product Details
MKT-112AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide:VQETKFGGAFSEEDCcorresponding to amino acid region 524-537 on Rat MERTK protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-mer proto-oncogene tyrosine kinase; MER receptor tyrosine kinase; MGC133349; novel cellular proto-oncogene; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; Tyro 12; Tyrosine-protein kinase Mer; unnamed protein product
Gene Aliases: c-Eyk; c-mer; Eyk; MER; MERTK; nmf12; Nyk; rdy; RP38; Tyro12
UniProt ID: (Human) Q12866, (Mouse) Q60805, (Rat) P57097
Entrez Gene ID: (Human) 10461, (Mouse) 17289, (Rat) 65037
natural killer cell differentiation
negative regulation of cytokine production
protein phosphorylation
phagocytosis
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
spermatogenesis
nervous system development
cell migration
platelet activation
secretion by cell
substrate adhesion-dependent cell spreading
apoptotic cell clearance
lymphocyte activation
positive regulation of phagocytosis
negative regulation of lymphocyte activation
establishment of localization in cell
positive regulation of protein kinase B signaling
retina development in camera-type eye
vagina development
neutrophil clearance
negative regulation of leukocyte apoptotic process
phosphorylation
protein kinase B signaling
peptidyl-tyrosine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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