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|Tested species reactivity||Mouse, Human, Primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (72 RPHTGNVAIPQVTSVESK 89) of MERTK protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.5-2 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MERTK is a novel transmembrane, receptor-like tyrosine kinase belonging to the MER/AXL/TYRO3 receptor kinase family with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and a tyrosine kinase domain. MERTK, a membrane protein, may have a functional role in filovirus infection, where it may act as a cell entry factor. MERTK is a GAS6 receptor, participating through binding to GAS6 in platelet function and platelet dependent thrombosis in vitro. Defects in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). It is usually detected in normal peripheral blood monocytes, macrophages, bone marrow, and tissues of epithelial and reproductive origin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
c-mer; MER; MER receptor tyrosine kinase; proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase Mer; receptor tyrosine kinase MerTK; RP38; STK kinase; Tyro 12; tyrosine-protein kinase Mer
c-mer; Eyk; MER; nmf12; Nyk; RP38
Protein metabolism and modification Protein modification Protein phosphorylation Signal transduction Cell surface receptor mediated signal transduction Receptor protein tyrosine kinase signaling pathway Immunity and defense Oncogenesis Developmental processes Fertilization Cell cycle Cell cycle control Cell structure and motility Cell motility Cell proliferation and differentiation