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Invitrogen
MESDC2 Polyclonal Antibody
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Product Details
PA5-58781
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MESDC2. Recombinant protein control fragment (Product #RP-98052).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLFNANYDVQ RFIVGSDRAI FMLRDGSYAW EIKDFLVGQD RCADVTLEGQ VYPGKGGGSK EKNKTKQDKG KKKKEGDLKS RSSK
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
Target Information
MESDC2 chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LDLR chaperone MESD; LRP chaperone MESD; Mesoderm development candidate 2; Mesoderm development LRP chaperone MESD; Mesoderm development protein; Renal carcinoma antigen NY-REN-61
Gene Aliases: BOCA; KIAA0081; MESD; MESDC2; MESDM; UNQ1911/PRO4369
UniProt ID: (Human) Q14696
Entrez Gene ID: (Human) 23184
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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