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Invitrogen
MESP1 Polyclonal Antibody
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FIGURE: 1 / 2
MESP1 Antibody (PA5-49441) in WB
Western blot analysis of MESP1 in mouse pancreas lysates . Samples were incubated with MESP1 polyclonal antibody (Product # PA5-49441) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Predicted band size: 26 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-49441
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 138-173 amino acids from the Central region of Mouse Mesp1.
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
120 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Mesp1 (mesoderm posterior 1) is a basic helix-loop-helix-type transcription factor, which along with its related proteins, has an essential role in both segmentation and rostro-caudal patterning of somites in the anterior pre-somitic mesoderm. Mesp1 is expressed in many of the precursors of the cardiovascular system and is known to play a role in the process of cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Mesoderm posterior protein 1; MGC10676
Gene Aliases: bHLHc5; Mesp1
UniProt ID: (Mouse) P97309
Entrez Gene ID: (Mouse) 17292
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
enhancer binding
transcription regulatory region DNA binding
protein dimerization activity
heart looping
heart morphogenesis
secondary heart field specification
embryonic heart tube morphogenesis
cardiac atrium formation
cardiac ventricle formation
sinus venosus morphogenesis
growth involved in heart morphogenesis
cardioblast migration
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
mesodermal cell migration
neurogenesis
signal transduction involved in regulation of gene expression
positive regulation of Notch signaling pathway involved in heart induction
negative regulation of mesodermal cell fate specification
negative regulation of endodermal cell fate specification
endothelial cell differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of striated muscle cell differentiation
cardiac muscle cell differentiation
cardiac cell fate determination
sinoatrial node cell differentiation
cardiac vascular smooth muscle cell differentiation
cardioblast migration to the midline involved in heart field formation
positive regulation of hepatocyte differentiation
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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