This target displays homology in the following species: Mouse: 100%; Rat: 93%
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mesoderm posterior protein 2
Gene Aliases: bHLHc6; Mesp2
UniProt ID: (Mouse) O08574
Entrez Gene ID: (Mouse) 17293