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Active Motif
METTL1/WDR4 Polyclonal Antibody
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Product Details
65113ACTMOTIF
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This antibody was raised against a human peptide containing methyltransferase 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs). METTL14 (methyltransferase-like 14) forms a stable N6 methyltransferase heterodimer complex with METTL3, which catalyzes the generation of m6A modification on mammalian nuclear RNAs. METTL3 is the catalytically active subunit, while METTL14 plays a structural role critical for substrate recognition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: D1075-like gene product; hWH; Methyltransferase-like protein 1; METTL1; miRNA (guanine-N(7)-)-methyltransferase; mRNA (guanine-N(7)-)-methyltransferase; Protein Wuho homolog; TRM82 tRNA methyltransferase 82 homolog; tRNA (guanine(46)-N(7))-methyltransferase; tRNA (guanine-N(7)-)-methyltransferase; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; tRNA(m7G46)-methyltransferase; WD repeat-containing protein 4; WDR4
Gene Aliases: C12orf1; METTL1; TRM8; TRM82; TRMT8; TRMT82; WDR4; YDL201w
UniProt ID: (Human) Q9UBP6, (Human) B4DNQ7
Entrez Gene ID: (Human) 4234, (Human) 10785
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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