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Proteintech
METTL3 Polyclonal Antibody
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Product Details
15073-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Fruit fly,
Human,
Mouse,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
METTL3 Fusion Protein Ag7110 (229-580 aa encoded by BC001650)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LNQQSTKEQ QSKKVSQEIL ELLNTTTAKE QSIVEKFRSR GRAQVQEFCD YGTKEECMKA SDADRPCRKL HFRRIINKHT DESLGDCSFL NTCFHMDTCK YVHYEIDACM DSEAPGSKDH TPSQELALTQ SVGGDSSADR LFPPQWICCD IRYLDVSILG KFAVVMADPP WDIHMELPYG TLTDDEMRRL NIPVLQDDGF LFLWVTGRAM ELGRECLNLW GYERVDEIIW VKTNQLQRII RTGRTGHWLN HGKEHCLVGV KGNPQGFNQG LDCDVIVAEV RSTSHKPDEI YGMIERLSPG TRKIELFGRP HNVQPNWITL GNQLDGIHLL DPDVVARFKQ RYPDGIISKP KNL (229-580 aa encoded by BC001650)
Target Information
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; m6a methyltransferase; methyltransferase-like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N(6)-adenosine-methyltransferase 70 kDa subunit; N(6)-adenosine-methyltransferase catalytic subunit METTL3; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase subunit METTL3
Gene Aliases: 2310024F18Rik; IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44, (Mouse) Q8C3P7
Entrez Gene ID: (Human) 56339, (Mouse) 56335, (Rat) 361035
mRNA binding
RNA methyltransferase activity
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
protein heterodimerization activity
S-adenosyl-L-methionine binding
mRNA (N6-adenosine)-methyltransferase activity
RNA binding
protein binding
methyltransferase activity
transferase activity
RNA metabolism protein
RNA methyltransferase
nucleic acid metabolism protein
mRNA splicing, via spliceosome
RNA methylation
adenosine to inosine editing
mRNA processing
circadian rhythm
gene expression
stem cell population maintenance
primary miRNA processing
mRNA destabilization
mRNA methylation
positive regulation of cap-independent translational initiation
primary miRNA methylation
nucleobase-containing compound metabolic process
mRNA modification
methylation
rhythmic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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