Proteintech

METTL3 Polyclonal Antibody

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METTL3 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using 15073-1-AP ( METTL3 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

METTL3 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with 15073-1-AP (METTL3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

METTL3 Antibody in Immunoprecipitation (IP) — IP result of anti-METTL3 (IP:15073-1-AP, 4 ug; Detection:15073-1-AP 1:300) with HEK-293 cells lysate 3000 ug.

Product Details

15073-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 258 publications 258 publications

Immunohistochemistry (IHC)

View 48 publications 48 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 29 publications 29 publications

Flow Cytometry (Flow)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 16 publications 16 publications

ChIP assay (ChIP)

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 14 publications 14 publications

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Published species

Fruit fly, Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

METTL3 Fusion Protein Ag7110 (229-580 aa encoded by BC001650)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: LNQQSTKEQ QSKKVSQEIL ELLNTTTAKE QSIVEKFRSR GRAQVQEFCD YGTKEECMKA SDADRPCRKL HFRRIINKHT DESLGDCSFL NTCFHMDTCK YVHYEIDACM DSEAPGSKDH TPSQELALTQ SVGGDSSADR LFPPQWICCD IRYLDVSILG KFAVVMADPP WDIHMELPYG TLTDDEMRRL NIPVLQDDGF LFLWVTGRAM ELGRECLNLW GYERVDEIIW VKTNQLQRII RTGRTGHWLN HGKEHCLVGV KGNPQGFNQG LDCDVIVAEV RSTSHKPDEI YGMIERLSPG TRKIELFGRP HNVQPNWITL GNQLDGIHLL DPDVVARFKQ RYPDGIISKP KNL (229-580 aa encoded by BC001650)

Target Information

METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

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Tue Aug 01 00:00:00 EDT 2023

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.

Cell reports

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Tue Jul 25 00:00:00 EDT 2023

METTL3 Contributes to Osteosarcoma Progression by Increasing DANCR mRNA Stability via m6A Modification.

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Thu Jul 20 00:00:00 EDT 2023

Y-box binding protein 1 influences zygotic genome activation by regulating N6-methyladenosine in porcine embryos.

Journal of cellular physiology

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Comprehensive analysis of long non-coding RNA expression profiles of GC-1spg cells with m6A methylation knockdown.

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Carcinogenesis

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METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.

Stem cells international

Han X,Li G,Yang H,Zhang C,Cao Y,Wang N,Ge L,Fan Z

Mon Jun 19 00:00:00 EDT 2023

METTL3 Promotes Osteo/Odontogenic Differentiation of Stem Cells by Inhibiting miR-196b-5p Maturation.

Stem cells international

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METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner†.

Biology of reproduction

Sun Y,Zhang XC,Li MD,Bu LG,Wang B,Li TY,Ding NZ,Ni H

Fri Jun 09 00:00:00 EDT 2023

Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.

Tissue & cell

Huang J,Guo C,Wang Y,Zhou Y

Thu Jun 01 00:00:00 EDT 2023

Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.

Tissue & cell

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Thu Jun 01 00:00:00 EDT 2023

Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.

Tissue & cell

Huang J,Guo C,Wang Y,Zhou Y

Thu Jun 01 00:00:00 EDT 2023

m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging.

Nature aging

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m⁶A epitranscriptomic regulation of tissue homeostasis during primate aging.

Nature aging

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The differences in biological behavior and gene expression characteristics between pure and mixed early gastric signet ring cell carcinomas.

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N6-methyladenosine participates in mouse hippocampus neurodegeneration via PD-1/PD-L1 pathway.

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N6-methyladenosine participates in mouse hippocampus neurodegeneration via PD-1/PD-L1 pathway.

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Fri May 19 00:00:00 EDT 2023

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RNA N6-methyladenosine reader IGF2BP3 interacts with MYCN and facilitates neuroblastoma cell proliferation.

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Wed May 03 00:00:00 EDT 2023

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Sat Apr 01 00:00:00 EDT 2023

N⁶-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.

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Journal of virology

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Rewired m⁶A epitranscriptomic networks link mutant p53 to neoplastic transformation.

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METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1.

PeerJ

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Tue Mar 14 00:00:00 EDT 2023

MetBil as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification.

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Wed Mar 01 00:00:00 EST 2023

MetBil as a novel molecular regulator in ischemia-induced cardiac fibrosis via METTL3-mediated m6A modification.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Wed Mar 01 00:00:00 EST 2023

Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis.

Immunology

Gou Y,Wang H,Wang T,Wang H,Wang B,Jiao N,Yu Y,Cao Y,Wang H,Zhang Z

Wed Mar 01 00:00:00 EST 2023

ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang T,Zhou LY,Li XM,Liu F,Liang L,Chen XZ,Ju J,Ponnusamy M,Wang K,Liu CY,Yan KW,Wang K

Wed Mar 01 00:00:00 EST 2023

ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.

Molecular therapy : the journal of the American Society of Gene Therapy

Wang T,Zhou LY,Li XM,Liu F,Liang L,Chen XZ,Ju J,Ponnusamy M,Wang K,Liu CY,Yan KW,Wang K

Wed Mar 01 00:00:00 EST 2023

Heterogeneous Nuclear Protein U Degraded the m⁶A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.

Journal of virology

Zhou H,Yan Y,Gao J,Ma M,Liu Y,Shi X,Zhang Q,Xu X

Tue Feb 28 00:00:00 EST 2023

Splice site m⁶A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.

PeerJ

Li X,Fang J,Tao X,Xia J,Cheng B,Wang Y

Fri Feb 24 00:00:00 EST 2023

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3.

Environmental science & technology

Li S,Xu S,Chen Y,Zhou J,Ben S,Guo M,Chu H,Gu D,Zhang Z,Wang M

Tue Feb 21 00:00:00 EST 2023

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3.

Environmental science & technology

Li S,Xu S,Chen Y,Zhou J,Ben S,Guo M,Chu H,Gu D,Zhang Z,Wang M

Tue Feb 21 00:00:00 EST 2023

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3.

Environmental science & technology

Li S,Xu S,Chen Y,Zhou J,Ben S,Guo M,Chu H,Gu D,Zhang Z,Wang M

Tue Feb 21 00:00:00 EST 2023

Metal Exposure Promotes Colorectal Tumorigenesis via the Aberrant N⁶-Methyladenosine Modification of ATP13A3.

Environmental science & technology

Li S,Xu S,Chen Y,Zhou J,Ben S,Guo M,Chu H,Gu D,Zhang Z,Wang M

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The m⁶A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease.

Pediatric surgery international

Huang Z,Luo C,Hou X,Yu D,Su Y,Li X,Luo Y,Liao G,Mu J,Wu K

Wed Feb 15 00:00:00 EST 2023

The m⁶A methyltransferase METTL3 affects cell proliferation and migration by regulating YAP expression in Hirschsprung disease.

Pediatric surgery international

Huang Z,Luo C,Hou X,Yu D,Su Y,Li X,Luo Y,Liao G,Mu J,Wu K

Wed Feb 15 00:00:00 EST 2023

RBM10 recruits METTL3 to induce N6-methyladenosine-MALAT1-dependent modification, inhibiting the invasion and migration of NSCLC.

Life sciences

Cao Y,Di X,Cong S,Tian C,Wang Y,Jin X,Zhao M,Zhou X,Li R,Wang K

Wed Feb 15 00:00:00 EST 2023

Novel RNA N6-methyladenosine regulator related signature for predicting clinical and immunological characteristics in breast cancer.

Gene

Zhang J,Liu G,Dai Z,Xie F,Zheng R,Yuan B,Guo L

Wed Feb 15 00:00:00 EST 2023

N⁶-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.

Microbiology spectrum

Khan O,Tanuj GN,Choravada DR,Rajak KK,Chandra Sekar S,Lingaraju MC,Dhara SK,Gupta PK,Mishra BP,Dutt T,Gandham RK,Sajjanar B

Tue Feb 14 00:00:00 EST 2023

N⁶-Methyladenosine RNA Modification in Host Cells Regulates Peste des Petits Ruminants Virus Replication.

Microbiology spectrum

Khan O,Tanuj GN,Choravada DR,Rajak KK,Chandra Sekar S,Lingaraju MC,Dhara SK,Gupta PK,Mishra BP,Dutt T,Gandham RK,Sajjanar B

Tue Feb 14 00:00:00 EST 2023

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Molecular medicine (Cambridge, Mass.)

Chen Y,Liu X,Li L,He X,Zheng F,Zhang Y,Gao H,Jin Z,Wu D,Wang Q,Tao H,Zhao Y,Liu W,Zou L

Mon Feb 06 00:00:00 EST 2023

Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Molecular medicine (Cambridge, Mass.)

Chen Y,Liu X,Li L,He X,Zheng F,Zhang Y,Gao H,Jin Z,Wu D,Wang Q,Tao H,Zhao Y,Liu W,Zou L

Mon Feb 06 00:00:00 EST 2023

F-Box Protein 43, Stabilized by N6-Methyladenosine Methylation, Enhances Hepatocellular Carcinoma Cell Growth and Invasion via Promoting p53 Degradation in a Ubiquitin Conjugating Enzyme E2 C-Dependent Manner.

Cancers

Zhou H,Zeng C,Liu J,Luo H,Huang W

Thu Feb 02 00:00:00 EST 2023

Cancers

Zhou H,Zeng C,Liu J,Luo H,Huang W

Thu Feb 02 00:00:00 EST 2023

m ⁶ A RNA methylation orchestrates transcriptional dormancy during developmental pausing.

bioRxiv : the preprint server for biology

Collignon E,Cho B,Fothergill-Robinson J,Furlan G,Ross RL,Limbach PA,Ramalho-Santos M

Wed Feb 01 00:00:00 EST 2023

IL-17A promotes endothelial cell senescence by up-regulating the expression of FTO through activating JNK signal pathway.

Biogerontology

Li N,Luo R,Zhang W,Wu Y,Hu C,Liu M,Jiang D,Jiang Z,Zhao X,Wang Y,Li Q

Wed Feb 01 00:00:00 EST 2023

FTO-dependent m⁶A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Nature communications

Li B,Xi W,Bai Y,Liu X,Zhang Y,Li L,Bian L,Liu C,Tang Y,Shen L,Yang L,Gu X,Xie J,Zhou Z,Wang Y,Yu X,Wang J,Chao J,Han B,Yao H

Mon Jan 30 00:00:00 EST 2023

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Acta biochimica et biophysica Sinica

Du P,Meng L,Liao X,Liu Y,Mo X,Gong M,Liao Y

Wed Jan 25 00:00:00 EST 2023

METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.

International journal of molecular sciences

Li D,He J,Fang C,Zhang Y,He M,Zhang Z,Hou J,Xu Q

Wed Jan 11 00:00:00 EST 2023

Crosstalk between 5-methylcytosine and N⁶-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.

Molecular cancer

Tian Y,Xiao H,Yang Y,Zhang P,Yuan J,Zhang W,Chen L,Fan Y,Zhang J,Cheng H,Deng T,Yang L,Wang W,Chen G,Wang P,Gong P,Niu X,Zhang X

Tue Jan 10 00:00:00 EST 2023

Involvement of METTL3 in arsenite-induced skin lesions by targeting the SOCS3/STAT3/Krt signaling pathway.

Environmental pollution (Barking, Essex : 1987)

Yang F,Zhang A

Sun Jan 01 00:00:00 EST 2023

Fusobacterium nucleatum stimulates cell proliferation and promotes PD-L1 expression via IFIT1-related signal in colorectal cancer.

Neoplasia (New York, N.Y.)

Gao Y,Zou T,Xu P,Wang Y,Jiang Y,Chen YX,Chen H,Hong J,Fang JY

Sun Jan 01 00:00:00 EST 2023

RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming.

Biochemical and biophysical research communications

Zheng L,Chen X,Yin Q,Gu J,Chen J,Chen M,Zhang Y,Dong M,Jiang H,Yin N,Chen H,Li X

Tue Dec 20 00:00:00 EST 2022

Stage-specific requirement for METTL3-dependent m⁶A modification during dental pulp stem cell differentiation.

Journal of translational medicine

Luo H,Liu W,Zhou Y,Zhang Y,Wu J,Wang R,Shao L

Fri Dec 16 00:00:00 EST 2022

Stage-specific requirement for METTL3-dependent m⁶A modification during dental pulp stem cell differentiation.

Journal of translational medicine

Luo H,Liu W,Zhou Y,Zhang Y,Wu J,Wang R,Shao L

Fri Dec 16 00:00:00 EST 2022

Stage-specific requirement for METTL3-dependent m⁶A modification during dental pulp stem cell differentiation.

Journal of translational medicine

Luo H,Liu W,Zhou Y,Zhang Y,Wu J,Wang R,Shao L

Fri Dec 16 00:00:00 EST 2022

Stage-specific requirement for METTL3-dependent m⁶A modification during dental pulp stem cell differentiation.

Journal of translational medicine

Luo H,Liu W,Zhou Y,Zhang Y,Wu J,Wang R,Shao L

Fri Dec 16 00:00:00 EST 2022

Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression.

Cell reports

Timcheva K,Dufour S,Touat-Todeschini L,Burnard C,Carpentier MC,Chuffart F,Merret R,Helsmoortel M,Ferré S,Grézy A,Couté Y,Rousseaux S,Khochbin S,Vourc'h C,Bousquet-Antonelli C,Kiernan R,Seigneurin-Berny D,Verdel A

Tue Dec 13 00:00:00 EST 2022

The m⁶A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis.

Molecular therapy : the journal of the American Society of Gene Therapy

Li Y,Kang X,Zhou Z,Pan L,Chen H,Liang X,Chu J,Dong S,Liu C,Yu S,Tu D,Zhang Y,Ge M,Chen W,Xu Y,Zhang Q

Wed Dec 07 00:00:00 EST 2022

mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.

Molecular therapy : the journal of the American Society of Gene Therapy

Pan J,Xie Y,Li H,Li X,Chen J,Liu X,Zhou J,Tang X,He Z,Peng Z,Zhang H,Li Y,Xiang X,Yuan Y,Zhang D

Wed Dec 07 00:00:00 EST 2022

mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.

Molecular therapy : the journal of the American Society of Gene Therapy

Pan J,Xie Y,Li H,Li X,Chen J,Liu X,Zhou J,Tang X,He Z,Peng Z,Zhang H,Li Y,Xiang X,Yuan Y,Zhang D

Wed Dec 07 00:00:00 EST 2022

mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis.

Molecular therapy : the journal of the American Society of Gene Therapy

Pan J,Xie Y,Li H,Li X,Chen J,Liu X,Zhou J,Tang X,He Z,Peng Z,Zhang H,Li Y,Xiang X,Yuan Y,Zhang D

Wed Dec 07 00:00:00 EST 2022

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10.

Cancer cell international

Cai J,Cui Z,Zhou J,Zhang B,Lu R,Ding Y,Hu H

Wed Dec 07 00:00:00 EST 2022

METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10.

Cancer cell international

Cai J,Cui Z,Zhou J,Zhang B,Lu R,Ding Y,Hu H

Wed Dec 07 00:00:00 EST 2022

Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism.

Frontiers in oncology

Peng G,Chen S,Zheng N,Tang Y,Su X,Wang J,Dong R,Wu D,Hu M,Zhao Y,Liu M,Wu H

Tue Dec 06 00:00:00 EST 2022

The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.

Cell death & disease

Liu M,Ruan X,Liu X,Dong W,Wang D,Yang C,Liu L,Wang P,Zhang M,Xue Y

Sat Dec 03 00:00:00 EST 2022

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Discover. Oncology

Kong F,Wang K,Wang L

Fri Nov 25 00:00:00 EST 2022

METTL3/m⁶A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.

Frontiers in pharmacology

Ge F,Li Z,Hu J,Pu Y,Zhao F,Kong L

Fri Nov 18 00:00:00 EST 2022

METTL3/m⁶A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.

Frontiers in pharmacology

Ge F,Li Z,Hu J,Pu Y,Zhao F,Kong L

Fri Nov 18 00:00:00 EST 2022

METTL3/m⁶A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.

Frontiers in pharmacology

Ge F,Li Z,Hu J,Pu Y,Zhao F,Kong L

Fri Nov 18 00:00:00 EST 2022

METTL3/m⁶A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.

Frontiers in pharmacology

Ge F,Li Z,Hu J,Pu Y,Zhao F,Kong L

Fri Nov 18 00:00:00 EST 2022

METTL3 upregulates COPS5 expression in osteosarcoma in an m⁶A-related manner to promote osteosarcoma progression.

Experimental cell research

Zhang C,Wan J,Liu Q,Long F,Wen Z,Liu Y

Tue Nov 15 00:00:00 EST 2022

METTL3 upregulates COPS5 expression in osteosarcoma in an m⁶A-related manner to promote osteosarcoma progression.

Experimental cell research

Zhang C,Wan J,Liu Q,Long F,Wen Z,Liu Y

Tue Nov 15 00:00:00 EST 2022

A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells.

PLoS biology

Porman AM,Roberts JT,Duncan ED,Chrupcala ML,Levine AA,Kennedy MA,Williams MM,Richer JK,Johnson AM

Tue Nov 01 00:00:00 EDT 2022

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Chemistry & biodiversity

Yang Y,Qian Cai Q,Sheng Fu L,Wei Dong Y,Fan F,Zhong Wu X

Tue Nov 01 00:00:00 EDT 2022

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Chemistry & biodiversity

Yang Y,Qian Cai Q,Sheng Fu L,Wei Dong Y,Fan F,Zhong Wu X

Tue Nov 01 00:00:00 EDT 2022

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Chemistry & biodiversity

Yang Y,Qian Cai Q,Sheng Fu L,Wei Dong Y,Fan F,Zhong Wu X

Tue Nov 01 00:00:00 EDT 2022

Adenosine N⁶-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.

Biochemical pharmacology

Isono M,Nakano M,Fukami T,Nakajima M

Tue Nov 01 00:00:00 EDT 2022

RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jiang T,He X,Zhao Z,Zhang X,Wang T,Jia L

Tue Nov 01 00:00:00 EDT 2022

N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

Clinical and translational medicine

Shi HZ,Xiong JS,Gan L,Zhang Y,Zhang CC,Kong YQ,Miao QJ,Tian CC,Li R,Liu JQ,Zhang EJ,Bu WB,Wang Y,Cheng XF,Sun JF,Chen H

Tue Nov 01 00:00:00 EDT 2022

Profiling RNA at chromatin targets in situ by antibody-targeted tagmentation.

Nature methods

Khyzha N,Henikoff S,Ahmad K

Tue Nov 01 00:00:00 EDT 2022

Metformin combats obesity by targeting FTO in an m⁶A-YTHDF2-dependent manner.

Journal of drug targeting

Liao X,Liu J,Chen Y,Liu Y,Chen W,Zeng B,Liu Y,Luo Y,Huang C,Guo G,Wang Y,Wang X

Tue Nov 01 00:00:00 EDT 2022

The N⁶-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

Nature communications

Yoshinaga M,Han K,Morgens DW,Horii T,Kobayashi R,Tsuruyama T,Hia F,Yasukura S,Kajiya A,Cai T,Cruz PHC,Vandenbon A,Suzuki Y,Kawahara Y,Hatada I,Bassik MC,Takeuchi O

Fri Oct 28 00:00:00 EDT 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 EDT 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 EDT 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 EDT 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 EDT 2022

METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Nature communications

Li Y,He X,Lu X,Gong Z,Li Q,Zhang L,Yang R,Wu C,Huang J,Ding J,He Y,Liu W,Chen C,Cao B,Zhou D,Shi Y,Chen J,Wang C,Zhang S,Zhang J,Ye J,You H

Wed Oct 26 00:00:00 EDT 2022

N⁶-Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1.

Journal of virology

Kim GW,Moon JS,Gudima SO,Siddiqui A

Wed Oct 12 00:00:00 EDT 2022

FTO-dependent N(6)-Methyladenosine regulates the progression of endometriosis via the ATG5/PKM2 Axis.

Cellular signalling

Wang H,Liang Z,Gou Y,Li Z,Cao Y,Jiao N,Tan J,Yu Y,Zhang Z

Sat Oct 01 00:00:00 EDT 2022

YTHDF3 modulates hematopoietic stem cells by recognizing RNA m⁶A modification on Ccnd1.

Haematologica

Zhang X,Cong T,Wei L,Zhong B,Wang X,Sun J,Wang S,Xu MM,Zhu P,Jiang H,Wang J

Sat Oct 01 00:00:00 EDT 2022

METTL3 suppresses anlotinib sensitivity by regulating m⁶A modification of FGFR3 in oral squamous cell carcinoma.

Cancer cell international

Chen J,Li S,Huang Z,Cao C,Wang A,He Q

Tue Sep 27 00:00:00 EDT 2022

METTL3 suppresses anlotinib sensitivity by regulating m⁶A modification of FGFR3 in oral squamous cell carcinoma.

Cancer cell international

Chen J,Li S,Huang Z,Cao C,Wang A,He Q

Tue Sep 27 00:00:00 EDT 2022

m⁶A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.

Cells

Bian Y,Wang Y,Xu S,Gao Z,Li C,Fan Z,Ding J,Wang K

Tue Sep 27 00:00:00 EDT 2022

m⁶A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization.

Cells

Bian Y,Wang Y,Xu S,Gao Z,Li C,Fan Z,Ding J,Wang K

Tue Sep 27 00:00:00 EDT 2022

Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis.

Cells

Zhou Y,Jiang R,Jiang Y,Fu Y,Manafhan Y,Zhu J,Jia E

Sat Sep 24 00:00:00 EDT 2022

Exploration of N6-Methyladenosine Profiles of mRNAs and the Function of METTL3 in Atherosclerosis.

Cells

Zhou Y,Jiang R,Jiang Y,Fu Y,Manafhan Y,Zhu J,Jia E

Sat Sep 24 00:00:00 EDT 2022

Mettl3-dependent m⁶A modification attenuates the brain stress response in Drosophila.

Nature communications

Perlegos AE,Shields EJ,Shen H,Liu KF,Bonini NM

Wed Sep 14 00:00:00 EDT 2022

CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.

Communications biology

Zhang M,Yang C,Ruan X,Liu X,Wang D,Liu L,Shao L,Wang P,Dong W,Xue Y

Mon Sep 05 00:00:00 EDT 2022

METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma.

International journal of oncology

Li M,Xia M,Zhang Z,Tan Y,Li E,Guo Z,Fang M,Zhu Y,Hu Z

Thu Sep 01 00:00:00 EDT 2022

METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.

Nature cancer

Zeng X,Zhao F,Cui G,Zhang Y,Deshpande RA,Chen Y,Deng M,Kloeber JA,Shi Y,Zhou Q,Zhang C,Hou J,Kim W,Tu X,Yan Y,Xu Z,Chen L,Gao H,Guo G,Liu J,Zhu Q,Cao Y,Huang J,Wu Z,Zhu S,Yin P,Luo K,Mer G,Paull TT,Yuan J,Tao K,Lou Z

Thu Sep 01 00:00:00 EDT 2022

METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma.

Nature cancer

Thu Sep 01 00:00:00 EDT 2022

M⁶A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.

Journal of oncology

Liu F,Zhang X,Liu Z,Cai W,Song C,Jiang Y,Yin J,Liu Z,Huang C

Sat Aug 27 00:00:00 EDT 2022

M⁶A Modifier-Mediated Methylation Characterized by Diverse Prognosis, Tumor Microenvironment, and Immunotherapy Response in Hepatocellular Carcinoma.

Journal of oncology

Liu F,Zhang X,Liu Z,Cai W,Song C,Jiang Y,Yin J,Liu Z,Huang C

Sat Aug 27 00:00:00 EDT 2022

The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.

International journal of biological sciences

Wu Q,Zhang H,Yang D,Min Q,Wang Y,Zhang W,Zhan Q

Mon Aug 22 00:00:00 EDT 2022

METTL3 promotes prostatic hyperplasia by regulating PTEN expression in an m⁶A-YTHDF2-dependent manner.

Cell death & disease

Li J,Yao H,Huang J,Li C,Zhang Y,Xu R,Wang Z,Long Z,Tang J,Wang L

Fri Aug 19 00:00:00 EDT 2022

PGE₂ -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

The EMBO journal

Tao X,Du R,Guo S,Feng X,Yu T,OuYang Q,Chen Q,Fan X,Wang X,Guo C,Li X,Xue F,Chen S,Tong M,Lazarus M,Zuo S,Yu Y,Shen Y

Tue Aug 16 00:00:00 EDT 2022

Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.

BMC genomics

Li W,Xing C,Bao L,Han S,Luo T,Wang Z,Fan H

Thu Aug 11 00:00:00 EDT 2022

Mettl3-mediated mRNA m⁶A modification controls postnatal liver development by modulating the transcription factor Hnf4a.

Nature communications

Xu Y,Zhou Z,Kang X,Pan L,Liu C,Liang X,Chu J,Dong S,Li Y,Liu Q,Sun Y,Yu S,Zhang Q

Fri Aug 05 00:00:00 EDT 2022

METTL14-dependent m⁶A modification controls iNKT cell development and function.

Cell reports

Cao L,Morgun E,Genardi S,Visvabharathy L,Cui Y,Huang H,Wang CR

Tue Aug 02 00:00:00 EDT 2022

Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions.

Environmental toxicology

Yang F,Zhang A

Mon Aug 01 00:00:00 EDT 2022

Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.

International journal of biological sciences

Li N,Yi X,He Y,Huo B,Chen Y,Zhang Z,Wang Q,Li Y,Zhong X,Li R,Zhu XH,Fang Z,Wei X,Jiang DS

Tue Jul 19 00:00:00 EDT 2022

3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.

International journal of bioprinting

Jiao X,Sun X,Li W,Chu W,Zhang Y,Li Y,Wang Z,Zhou X,Ma J,Xu C,Dai K,Wang J,Gan Y

Sat Jul 16 00:00:00 EDT 2022

3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner.

International journal of bioprinting

Jiao X,Sun X,Li W,Chu W,Zhang Y,Li Y,Wang Z,Zhou X,Ma J,Xu C,Dai K,Wang J,Gan Y

Sat Jul 16 00:00:00 EDT 2022

Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis.

Frontiers in physiology

Tian C,Chai J,Liu W,Zhang X,Li Y,Zuo H,Yuan G,Zhang H,Liu H,Chen Z

Sat Jul 16 00:00:00 EDT 2022

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Stem cell research & therapy

Zhou H,Shen X,Yan C,Xiong W,Ma Z,Tan Z,Wang J,Li Y,Liu J,Duan A,Liu F

Sat Jul 16 00:00:00 EDT 2022

Alternative splicing of METTL3 explains apparently METTL3-independent m6A modifications in mRNA.

PLoS biology

Poh HX,Mirza AH,Pickering BF,Jaffrey SR

Fri Jul 01 00:00:00 EDT 2022

Mettl3-mediated m⁶ A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xu B,Li Q,Wu Y,Wang H,Xu J,Liu H,Xuan A

Fri Jul 01 00:00:00 EDT 2022

Mettl3-mediated m⁶ A modification of Lrp2 facilitates neurogenesis through Ythdc2 and elicits antidepressant-like effects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xu B,Li Q,Wu Y,Wang H,Xu J,Liu H,Xuan A

Fri Jul 01 00:00:00 EDT 2022

METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression.

Cancer gene therapy

Chen HD,Li F,Chen S,Zhong ZH,Gao PF,Gao WZ

Fri Jul 01 00:00:00 EDT 2022

METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression.

Cancer gene therapy

Chen HD,Li F,Chen S,Zhong ZH,Gao PF,Gao WZ

Fri Jul 01 00:00:00 EDT 2022

METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation.

Cellular signalling

Kong Y,Zhang Y,Cai Y,Li D,Yi B,Xu Q

Fri Jul 01 00:00:00 EDT 2022

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Microbiology spectrum

Zhao L,Zhao Y,Liu Q,Huang J,Lu Y,Ping J

Wed Jun 29 00:00:00 EDT 2022

DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Microbiology spectrum

Zhao L,Zhao Y,Liu Q,Huang J,Lu Y,Ping J

Wed Jun 29 00:00:00 EDT 2022

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N⁶-methyladenosine.

Developmental cell

Lv D,Gimple RC,Zhong C,Wu Q,Yang K,Prager BC,Godugu B,Qiu Z,Zhao L,Zhang G,Dixit D,Lee D,Shen JZ,Li X,Xie Q,Wang X,Agnihotri S,Rich JN

Mon Jun 20 00:00:00 EDT 2022

Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.

Cancer science

Chen X,Liu Y,Sun D,Sun R,Wang X,Li M,Song N,Ying J,Guo T,Jiang Y

Wed Jun 01 00:00:00 EDT 2022

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Cancer letters

Yan R,Dai W,Wu R,Huang H,Shu M

Sat May 28 00:00:00 EDT 2022

RNA methylation-mediated LINC01559 suppresses colorectal cancer progression by regulating the miR-106b-5p/PTEN axis.

International journal of biological sciences

Shi K,Yang S,Chen C,Shao B,Guo Y,Wu X,Zhao L,Yang X,Zhang Q,Yuan W,Sun Z

Thu May 12 00:00:00 EDT 2022

Lactylation-driven METTL3-mediated RNA m⁶A modification promotes immunosuppression of tumor-infiltrating myeloid cells.

Molecular cell

Xiong J,He J,Zhu J,Pan J,Liao W,Ye H,Wang H,Song Y,Du Y,Cui B,Xue M,Zheng W,Kong X,Jiang K,Ding K,Lai L,Wang Q

Thu May 05 00:00:00 EDT 2022

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.

Cellular signalling

Cai Y,Yu R,Kong Y,Feng Z,Xu Q

Sun May 01 00:00:00 EDT 2022

N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

Li X,Gao Y,Chen W,Gu Y,Song J,Zhang J,Ai Y

Sun May 01 00:00:00 EDT 2022

METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation.

Journal of dental research

Cai W,Ji Y,Han L,Zhang J,Ni Y,Cheng Y,Zhang Y

Sun May 01 00:00:00 EDT 2022

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Frontiers in immunology

Li Z,Teng M,Jiang Y,Zhang L,Luo X,Liao Y,Yang B

Fri Apr 22 00:00:00 EDT 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 EDT 2022

METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.

Journal of Cancer

Li J,Li Z,Xu Y,Huang C,Shan B

Wed Apr 13 00:00:00 EDT 2022

METTL3 Facilitates Tumor Progression by COL12A1/MAPK Signaling Pathway in Esophageal Squamous Cell Carcinoma.

Journal of Cancer

Li J,Li Z,Xu Y,Huang C,Shan B

Wed Apr 13 00:00:00 EDT 2022

Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

Technology in cancer research & treatment

Wang Y,Zhao X,Li J,Wang X,Hu W,Zhang X

Tue Apr 05 00:00:00 EDT 2022

m⁶ A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.

Cancer communications (London, England)

Liu Y,Zhai E,Chen J,Qian Y,Zhao R,Ma Y,Liu J,Huang Z,Cai S,Chen J

Fri Apr 01 00:00:00 EDT 2022

m⁶ A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.

Cancer communications (London, England)

Liu Y,Zhai E,Chen J,Qian Y,Zhao R,Ma Y,Liu J,Huang Z,Cai S,Chen J

Fri Apr 01 00:00:00 EDT 2022

m⁶ A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.

Cancer communications (London, England)

Liu Y,Zhai E,Chen J,Qian Y,Zhao R,Ma Y,Liu J,Huang Z,Cai S,Chen J

Fri Apr 01 00:00:00 EDT 2022

m⁶ A-mediated regulation of PBX1-GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels.

Cancer communications (London, England)

Liu Y,Zhai E,Chen J,Qian Y,Zhao R,Ma Y,Liu J,Huang Z,Cai S,Chen J

Fri Apr 01 00:00:00 EDT 2022

Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing.

STAR protocols

Li N,Rana TM

Fri Mar 18 00:00:00 EDT 2022

m⁶A mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.

Frontiers in genetics

Guo F,Zhang Y,Ma J,Yu Y,Wang Q,Gao P,Wang L,Xu Z,Wei X,Jing M

Wed Mar 16 00:00:00 EDT 2022

Protective role of mRNA demethylase FTO on axon guidance molecules of nigro-striatal projection system in manganese-induced parkinsonism.

Journal of hazardous materials

Qi Z,Wang S,Li J,Wen Y,Cui R,Zhang K,Liu Y,Yang X,Zhang L,Xu B,Liu W,Xu Z,Deng Y

Tue Mar 15 00:00:00 EDT 2022

Decreased RNA m⁶A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.

American journal of cancer research

Tao M,Li X,He L,Rong X,Wang H,Pan J,Lu Z,Zhang X,Peng Y

Thu Mar 10 00:00:00 EST 2022

Decreased RNA m⁶A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.

American journal of cancer research

Tao M,Li X,He L,Rong X,Wang H,Pan J,Lu Z,Zhang X,Peng Y

Thu Mar 10 00:00:00 EST 2022

Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.

Cell biology and toxicology

Wu Y,Yang Z,Su S,Xu X,Li Y,Li X,Gao Y,Sun D,Wan S,Pen M,Jin W,Ke C

Sun Mar 06 00:00:00 EST 2022

lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus.

Cell death and differentiation

Liu HT,Zou YX,Zhu WJ,Zhang GH,Ma RR,Guo XY,Gao P

Tue Mar 01 00:00:00 EST 2022

AS3MT facilitates NLRP3 inflammasome activation by m⁶A modification during arsenic-induced hepatic insulin resistance.

Cell biology and toxicology

Qiu T,Wu C,Yao X,Han Q,Wang N,Yuan W,Zhang J,Shi Y,Jiang L,Liu X,Yang G,Sun X

Mon Feb 28 00:00:00 EST 2022

Aging-Associated Differences in Epitranscriptomic m6A Regulation in Response to Acute Cardiac Ischemia/Reperfusion Injury in Female Mice.

Frontiers in pharmacology

Su X,Shen Y,Jin Y,Kim IM,Weintraub NL,Tang Y

Wed Feb 23 00:00:00 EST 2022

Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA.

Journal of virology

Kim GW,Siddiqui A

Wed Feb 23 00:00:00 EST 2022

Validated Impacts of N6-Methyladenosine Methylated mRNAs on Apoptosis and Angiogenesis in Myocardial Infarction Based on MeRIP-Seq Analysis.

Frontiers in molecular biosciences

Zhang Y,Hua W,Dang Y,Cheng Y,Wang J,Zhang X,Teng M,Wang S,Zhang M,Kong Z,Lu X,Zheng Y

Wed Feb 16 00:00:00 EST 2022

TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

Chen J,Wei X,Wang X,Liu T,Zhao Y,Chen L,Luo Y,Du H,Li Y,Liu T,Cao L,Zhou Z,Zhang Z,Liang L,Li L,Yan X,Zhang X,Deng X,Yang G,Yin P,Hao J,Yin Z,You F

Tue Feb 15 00:00:00 EST 2022

TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

Chen J,Wei X,Wang X,Liu T,Zhao Y,Chen L,Luo Y,Du H,Li Y,Liu T,Cao L,Zhou Z,Zhang Z,Liang L,Li L,Yan X,Zhang X,Deng X,Yang G,Yin P,Hao J,Yin Z,You F

Tue Feb 15 00:00:00 EST 2022

TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

Chen J,Wei X,Wang X,Liu T,Zhao Y,Chen L,Luo Y,Du H,Li Y,Liu T,Cao L,Zhou Z,Zhang Z,Liang L,Li L,Yan X,Zhang X,Deng X,Yang G,Yin P,Hao J,Yin Z,You F

Tue Feb 15 00:00:00 EST 2022

TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

Chen J,Wei X,Wang X,Liu T,Zhao Y,Chen L,Luo Y,Du H,Li Y,Liu T,Cao L,Zhou Z,Zhang Z,Liang L,Li L,Yan X,Zhang X,Deng X,Yang G,Yin P,Hao J,Yin Z,You F

Tue Feb 15 00:00:00 EST 2022

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Brain research

Li M,Zhong X,Zhao Z,Zeng Z,Yuan Q,Xiao X,Zu X,Liu J

Tue Feb 15 00:00:00 EST 2022

Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.

European journal of pharmacology

Huang Y,Chen S,Pang L,Feng Z,Su H,Zhu W,Wei J

Tue Feb 15 00:00:00 EST 2022

N6-methyladenosine modification of the 5' epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein.

Proceedings of the National Academy of Sciences of the United States of America

Kim GW,Moon JS,Siddiqui A

Tue Feb 15 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice.

Cell death discovery

Yang L,Wu G,Wu Q,Peng L,Yuan L

Mon Feb 14 00:00:00 EST 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 EST 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 EST 2022

m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

The Journal of biological chemistry

Gao M,Qi Z,Feng W,Huang H,Xu Z,Dong Z,Xu M,Han J,Kloeber JA,Huang J,Lou Z,Liu S

Tue Feb 01 00:00:00 EST 2022

Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.

Frontiers in oncology

Li K,Gao S,Ma L,Sun Y,Peng ZY,Wu J,Du N,Ren H,Tang SC,Sun X

Tue Jan 25 00:00:00 EST 2022

N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.

Toxicological sciences : an official journal of the Society of Toxicology

Ning J,Du H,Zhang Y,Liu Q,Jiang T,Pang Y,Tian X,Yan L,Niu Y,Zhang R

Mon Jan 24 00:00:00 EST 2022

RNA N⁶-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice.

eLife

Li B,Zhang T,Liu M,Cui Z,Zhang Y,Liu M,Liu Y,Sun Y,Li M,Tian Y,Yang Y,Jiang H,Liang D

Mon Jan 10 00:00:00 EST 2022

Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.

Cell and tissue research

Liu Z,Cai Y,Deng M,Li D,Leng Q,Shi L,Tang Y,Wang F,Wan Y

Sat Jan 01 00:00:00 EST 2022

A defined N6-methyladenosine (m⁶A) profile conferred by METTL3 regulates muscle stem cell/myoblast state transitions.

Cell death discovery

Gheller BJ,Blum JE,Fong EHH,Malysheva OV,Cosgrove BD,Thalacker-Mercer AE

Fri Dec 31 00:00:00 EST 2021

m6A Modification-Mediated DUXAP8 Regulation of Malignant Phenotype and Chemotherapy Resistance of Hepatocellular Carcinoma Through miR-584-5p/MAPK1/ERK Pathway Axis.

Frontiers in cell and developmental biology

Liu Z,Lu J,Fang H,Sheng J,Cui M,Yang Y,Tang B,Zhang X

Tue Dec 28 00:00:00 EST 2021

Specific Regulation of m⁶A by SRSF7 Promotes the Progression of Glioblastoma.

Genomics, proteomics & bioinformatics

Cun Y,An S,Zheng H,Lan J,Chen W,Luo W,Yao C,Li X,Huang X,Sun X,Wu Z,Hu Y,Li Z,Zhang S,Wu G,Yang M,Tang M,Yu R,Liao X,Gao G,Zhao W,Wang J,Li J

Thu Dec 23 00:00:00 EST 2021

Specific Regulation of m⁶A by SRSF7 Promotes the Progression of Glioblastoma.

Genomics, proteomics & bioinformatics

Cun Y,An S,Zheng H,Lan J,Chen W,Luo W,Yao C,Li X,Huang X,Sun X,Wu Z,Hu Y,Li Z,Zhang S,Wu G,Yang M,Tang M,Yu R,Liao X,Gao G,Zhao W,Wang J,Li J

Thu Dec 23 00:00:00 EST 2021

Dynamic regulation of N⁶,2'-O-dimethyladenosine (m⁶Am) in obesity.

Nature communications

Ben-Haim MS,Pinto Y,Moshitch-Moshkovitz S,Hershkovitz V,Kol N,Diamant-Levi T,Beeri MS,Amariglio N,Cohen HY,Rechavi G

Fri Dec 10 00:00:00 EST 2021

YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.

Cancer cell international

Zhu X,Yang H,Zhang M,Wu X,Jiang L,Liu X,Lv K

Sat Dec 04 00:00:00 EST 2021

Loss of m⁶A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.

Pharmacological research

Gong R,Wang X,Li H,Liu S,Jiang Z,Zhao Y,Yu Y,Han Z,Yu Y,Dong C,Li S,Xu B,Zhang W,Wang N,Li X,Gao X,Yang F,Bamba D,Ma W,Liu Y,Cai B

Wed Dec 01 00:00:00 EST 2021

Loss of m⁶A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury.

Pharmacological research

Gong R,Wang X,Li H,Liu S,Jiang Z,Zhao Y,Yu Y,Han Z,Yu Y,Dong C,Li S,Xu B,Zhang W,Wang N,Li X,Gao X,Yang F,Bamba D,Ma W,Liu Y,Cai B

Wed Dec 01 00:00:00 EST 2021

Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.

PLoS pathogens

Xue M,Zhang Y,Wang H,Kairis EL,Lu M,Ahmad S,Attia Z,Harder O,Zhang Z,Wei J,Chen P,Gao Y,Peeples ME,Sharma A,Boyaka P,He C,Hur S,Niewiesk S,Li J

Wed Dec 01 00:00:00 EST 2021

Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.

Biology of reproduction

Li X,Xiong W,Long X,Dai X,Peng Y,Xu Y,Zhang Z,Zhang L,Liu Y

Mon Nov 15 00:00:00 EST 2021

Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.

Biology of reproduction

Li X,Xiong W,Long X,Dai X,Peng Y,Xu Y,Zhang Z,Zhang L,Liu Y

Mon Nov 15 00:00:00 EST 2021

Inhibition of METTL3/m6A/miR126 promotes the migration and invasion of endometrial stromal cells in endometriosis†.

Biology of reproduction

Li X,Xiong W,Long X,Dai X,Peng Y,Xu Y,Zhang Z,Zhang L,Liu Y

Mon Nov 15 00:00:00 EST 2021

m⁶A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity.

Cell reports

Qin Y,Li B,Arumugam S,Lu Q,Mankash SM,Li J,Sun B,Li J,Flavell RA,Li HB,Ouyang X

Tue Nov 09 00:00:00 EST 2021

N6-methyladenosine regulates ATM expression and downstream signaling.

Journal of Cancer

Zhang X,Liu P,Zheng X,Wang J,Peng Q,Li Z,Wei L,Liu C,Wu Y,Wen Y,Yan Q,Ma J

Fri Nov 05 00:00:00 EDT 2021

Degradation of WTAP blocks antiviral responses by reducing the m⁶ A levels of IRF3 and IFNAR1 mRNA.

EMBO reports

Ge Y,Ling T,Wang Y,Jia X,Xie X,Chen R,Chen S,Yuan S,Xu A

Thu Nov 04 00:00:00 EDT 2021

Characterization of Long Non-coding RNAs Modified by m⁶A RNA Methylation in Skeletal Myogenesis.

Frontiers in cell and developmental biology

Xie SJ,Tao S,Diao LT,Li PL,Chen WC,Zhou ZG,Hu YX,Hou YR,Lei H,Xu WY,Chen WJ,Peng YW,Zhang Q,Xiao ZD

Tue Nov 02 00:00:00 EDT 2021

Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.

Frontiers in oncology

Lv W,Wang Y,Zhao C,Tan Y,Xiong M,Yi Y,He X,Ren Y,Wu Y,Zhang Q

Tue Nov 02 00:00:00 EDT 2021

Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.

Frontiers in oncology

Lv W,Wang Y,Zhao C,Tan Y,Xiong M,Yi Y,He X,Ren Y,Wu Y,Zhang Q

Tue Nov 02 00:00:00 EDT 2021

m⁶A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Biochemical pharmacology

Takemoto S,Nakano M,Fukami T,Nakajima M

Mon Nov 01 00:00:00 EDT 2021

Dynamic m⁶A mRNA Methylation Reveals the Role of METTL3/14-m⁶A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration.

Frontiers in cell and developmental biology

Xie SJ,Lei H,Yang B,Diao LT,Liao JY,He JH,Tao S,Hu YX,Hou YR,Sun YJ,Peng YW,Zhang Q,Xiao ZD

Fri Oct 22 00:00:00 EDT 2021

Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.

BioMed research international

Cheng Z,Gao S,Liang X,Lian C,Chen J,Fang C

Tue Oct 19 00:00:00 EDT 2021

Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis.

BioMed research international

Cheng Z,Gao S,Liang X,Lian C,Chen J,Fang C

Tue Oct 19 00:00:00 EDT 2021

METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.

Cell death discovery

Zhao K,Yang C,Zhang J,Sun W,Zhou B,Kong X,Shi J

Wed Oct 13 00:00:00 EDT 2021

METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.

Cell death discovery

Zhao K,Yang C,Zhang J,Sun W,Zhou B,Kong X,Shi J

Wed Oct 13 00:00:00 EDT 2021

Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library.

Nature methods

Zhang Z,Chen T,Chen HX,Xie YY,Chen LQ,Zhao YL,Liu BD,Jin L,Zhang W,Liu C,Ma DZ,Chai GS,Zhang Y,Zhao WS,Ng WH,Chen J,Jia G,Yang J,Luo GZ

Fri Oct 01 00:00:00 EDT 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Molecular cancer

Liu X,Liu Y,Liu Z,Lin C,Meng F,Xu L,Zhang X,Zhang C,Zhang P,Gong S,Wu N,Ren Z,Song J,Zhang Y

Wed Sep 08 00:00:00 EDT 2021

Vitamin B₁₂ Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Molecular nutrition & food research

Mosca P,Robert A,Alberto JM,Meyer M,Kundu U,Hergalant S,Umoret R,Coelho D,Guéant JL,Leheup B,Dreumont N

Wed Sep 01 00:00:00 EDT 2021

Multiomics analysis identifies key genes and pathways related to N6-methyladenosine RNA modification in ovarian cancer.

Epigenomics

Xu H,Li X,Wang S,Li F,Gao J,Yan L,Zhu L

Wed Sep 01 00:00:00 EDT 2021

YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways.

Cellular signalling

Fang C,He M,Li D,Xu Q

Wed Sep 01 00:00:00 EDT 2021

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.

mBio

Zhang X,Hao H,Ma L,Zhang Y,Hu X,Chen Z,Liu D,Yuan J,Hu Z,Guan W

Tue Aug 31 00:00:00 EDT 2021

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.

mBio

Zhang X,Hao H,Ma L,Zhang Y,Hu X,Chen Z,Liu D,Yuan J,Hu Z,Guan W

Tue Aug 31 00:00:00 EDT 2021

Identification of an N6-methyladenosine-mediated positive feedback loop that promotes Epstein-Barr virus infection.

The Journal of biological chemistry

Dai DL,Li X,Wang L,Xie C,Jin Y,Zeng MS,Zuo Z,Xia TL

Mon Aug 23 00:00:00 EDT 2021

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer.

Molecular cell

Einstein JM,Perelis M,Chaim IA,Meena JK,Nussbacher JK,Tankka AT,Yee BA,Li H,Madrigal AA,Neill NJ,Shankar A,Tyagi S,Westbrook TF,Yeo GW

Thu Aug 05 00:00:00 EDT 2021

The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

The Journal of experimental medicine

Ma S,Yan J,Barr T,Zhang J,Chen Z,Wang LS,Sun JC,Chen J,Caligiuri MA,Yu J

Mon Aug 02 00:00:00 EDT 2021

Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

Journal of reproductive immunology

Zhao S,Lu J,Chen Y,Wang Z,Cao J,Dong Y

Sun Aug 01 00:00:00 EDT 2021

Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.

Journal of reproductive immunology

Zhao S,Lu J,Chen Y,Wang Z,Cao J,Dong Y

Sun Aug 01 00:00:00 EDT 2021

KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy.

Pharmacological research

Qi Y,Yao R,Zhang W,Cui Q

Sun Aug 01 00:00:00 EDT 2021

Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.

Molecular neurobiology

Xue A,Huang Y,Li M,Wei Q,Bu Q

Sun Aug 01 00:00:00 EDT 2021

METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.

Life sciences

Sang W,Xue S,Jiang Y,Lu H,Zhu L,Wang C,Ma J

Sun Aug 01 00:00:00 EDT 2021

N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.

Theranostics

Chen C,Yuan W,Zhou Q,Shao B,Guo Y,Wang W,Yang S,Guo Y,Zhao L,Dang Q,Yang X,Wang G,Kang Q,Ji Z,Liu J,Sun Z

Thu Jul 29 00:00:00 EDT 2021

Alteration of N6-Methyladenosine RNA Profiles in Cisplatin-Induced Acute Kidney Injury in Mice.

Frontiers in molecular biosciences

Li CM,Li M,Zhao WB,Ye ZC,Peng H

Tue Jul 27 00:00:00 EDT 2021

N⁶-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.

Cancer cell

Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG

Mon Jul 12 00:00:00 EDT 2021

The m⁶A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis.

Science immunology

Bechara R,Amatya N,Bailey RD,Li Y,Aggor FEY,Li DD,Jawale CV,Coleman BM,Dai N,Gokhale NS,Taylor TC,Horner SM,Poholek AC,Bansal A,Biswas PS,Gaffen SL

Fri Jul 02 00:00:00 EDT 2021

Regulation of telomere homeostasis and genomic stability in cancer by N ⁶-adenosine methylation (m⁶A).

Science advances

Lee JH,Hong J,Zhang Z,de la Peña Avalos B,Proietti CJ,Deamicis AR,Guzmán G P,Lam HM,Garcia J,Roudier MP,Sisk AE,De La Rosa R,Vu K,Yang M,Liao Y,Scheirer J,Pechacek D,Yadav P,Rao MK,Zheng S,Johnson-Pais TL,Leach RJ,Elizalde PV,Dray E,Xu K

Thu Jul 01 00:00:00 EDT 2021

Regulation of telomere homeostasis and genomic stability in cancer by N ⁶-adenosine methylation (m⁶A).

Science advances

Thu Jul 01 00:00:00 EDT 2021

The N⁶-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.

Biochemical pharmacology

Ondo K,Isono M,Nakano M,Hashiba S,Fukami T,Nakajima M

Thu Jul 01 00:00:00 EDT 2021

N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.

Frontiers in oncology

Tan L,Tang Y,Li H,Li P,Ye Y,Cen J,Gui C,Luo J,Cao J,Wei J

Sat Jun 26 00:00:00 EDT 2021

YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.

Biochemical and biophysical research communications

Jiang D,Hou J,Qian Y,Gao Y,Gao X,Wei S

Fri Jun 11 00:00:00 EDT 2021

RNA m⁶ A methylation regulates virus-host interaction and EBNA2 expression during Epstein-Barr virus infection.

Immunity, inflammation and disease

Zheng X,Wang J,Zhang X,Fu Y,Peng Q,Lu J,Wei L,Li Z,Liu C,Wu Y,Yan Q,Ma J

Tue Jun 01 00:00:00 EDT 2021

mTORC1 promotes cell growth via m⁶A-dependent mRNA degradation.

Molecular cell

Cho S,Lee G,Pickering BF,Jang C,Park JH,He L,Mathur L,Kim SS,Jung S,Tang HW,Monette S,Rabinowitz JD,Perrimon N,Jaffrey SR,Blenis J

Thu May 20 00:00:00 EDT 2021

METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.

Cell reports

Li N,Hui H,Bray B,Gonzalez GM,Zeller M,Anderson KG,Knight R,Smith D,Wang Y,Carlin AF,Rana TM

Tue May 11 00:00:00 EDT 2021

Binding of RNA m6A by IGF2BP3 triggers chemoresistance of HCT8 cells via upregulation of ABCB1.

American journal of cancer research

Yang Z,Zhao F,Gu X,Feng L,Xu M,Li T,Liu X,Zhang X

Fri May 07 00:00:00 EDT 2021

METTL3 regulates skeletal muscle specific miRNAs at both transcriptional and post-transcriptional levels.

Biochemical and biophysical research communications

Diao LT,Xie SJ,Lei H,Qiu XS,Huang MC,Tao S,Hou YR,Hu YX,Sun YJ,Zhang Q,Xiao ZD

Fri May 07 00:00:00 EDT 2021

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.

PLoS pathogens

Yang R,Lee EE,Kim J,Choi JH,Kolitz E,Chen Y,Crewe C,Salisbury NJH,Scherer PE,Cockerell C,Smith TR,Rosen L,Verlinden L,Galloway DA,Buck CB,Feltkamp MC,Sullivan CS,Wang RC

Sat May 01 00:00:00 EDT 2021

Role of epigenetic m⁶ A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Parial R,Li H,Li J,Archacki S,Yang Z,Wang IZ,Chen Q,Xu C,Wang QK

Sat May 01 00:00:00 EDT 2021

Nonsegmented Negative-Sense RNA Viruses Utilize N⁶-Methyladenosine (m⁶A) as a Common Strategy To Evade Host Innate Immunity.

Journal of virology

Lu M,Xue M,Wang HT,Kairis EL,Ahmad S,Wei J,Zhang Z,Liu Q,Zhang Y,Gao Y,Garcin D,Peeples ME,Sharma A,Hur S,He C,Li J

Mon Apr 12 00:00:00 EDT 2021

Autophagy of the m⁶A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Nature communications

Cui YH,Yang S,Wei J,Shea CR,Zhong W,Wang F,Shah P,Kibriya MG,Cui X,Ahsan H,He C,He YY

Mon Apr 12 00:00:00 EDT 2021

Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m⁶A-GPR161 signalling axis.

RNA biology

Zong X,Wang H,Xiao X,Zhang Y,Hu Y,Wang F,Wang Y,Lu Z

Thu Apr 01 00:00:00 EDT 2021

Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m⁶A-GPR161 signalling axis.

RNA biology

Zong X,Wang H,Xiao X,Zhang Y,Hu Y,Wang F,Wang Y,Lu Z

Thu Apr 01 00:00:00 EDT 2021

m⁶A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype.

Nature cell biology

Liu P,Li F,Lin J,Fukumoto T,Nacarelli T,Hao X,Kossenkov AV,Simon MC,Zhang R

Thu Apr 01 00:00:00 EDT 2021

N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition.

Proceedings of the National Academy of Sciences of the United States of America

Kim GW,Siddiqui A

Tue Mar 09 00:00:00 EST 2021

N⁶-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.

Developmental cell

Wang X,Liu C,Zhang S,Yan H,Zhang L,Jiang A,Liu Y,Feng Y,Li D,Guo Y,Hu X,Lin Y,Bu P,Li D

Mon Mar 08 00:00:00 EST 2021

N⁶-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.

Developmental cell

Wang X,Liu C,Zhang S,Yan H,Zhang L,Jiang A,Liu Y,Feng Y,Li D,Guo Y,Hu X,Lin Y,Bu P,Li D

Mon Mar 08 00:00:00 EST 2021

MYC promotes cancer progression by modulating m⁶ A modifications to suppress target gene translation.

EMBO reports

Wu G,Suo C,Yang Y,Shen S,Sun L,Li ST,Zhou Y,Yang D,Wang Y,Cai Y,Wang N,Zhang H,Yang YG,Cao J,Gao P

Wed Mar 03 00:00:00 EST 2021

N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.

PLoS pathogens

Chen S,Kumar S,Espada CE,Tirumuru N,Cahill MP,Hu L,He C,Wu L

Mon Mar 01 00:00:00 EST 2021

Oncogenic AURKA-enhanced N⁶-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.

Cell research

Peng F,Xu J,Cui B,Liang Q,Zeng S,He B,Zou H,Li M,Zhao H,Meng Y,Chen J,Liu B,Lv S,Chu P,An F,Wang Z,Huang J,Zhan Y,Liao Y,Lu J,Xu L,Zhang J,Sun Z,Li Z,Wang F,Lam EW,Liu Q

Mon Mar 01 00:00:00 EST 2021

The RNA m⁶A reader YTHDC1 silences retrotransposons and guards ES cell identity.

Nature

Liu J,Gao M,He J,Wu K,Lin S,Jin L,Chen Y,Liu H,Shi J,Wang X,Chang L,Lin Y,Zhao YL,Zhang X,Zhang M,Luo GZ,Wu G,Pei D,Wang J,Bao X,Chen J

Mon Mar 01 00:00:00 EST 2021

RNA N⁶-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m⁶A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.

Gastroenterology

Chen H,Gao S,Liu W,Wong CC,Wu J,Wu J,Liu D,Gou H,Kang W,Zhai J,Li C,Su H,Wang S,Soares F,Han J,He HH,Yu J

Mon Mar 01 00:00:00 EST 2021

RNA N⁶-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m⁶A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.

Gastroenterology

Chen H,Gao S,Liu W,Wong CC,Wu J,Wu J,Liu D,Gou H,Kang W,Zhai J,Li C,Su H,Wang S,Soares F,Han J,He HH,Yu J

Mon Mar 01 00:00:00 EST 2021

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Nature

Xu W,Li J,He C,Wen J,Ma H,Rong B,Diao J,Wang L,Wang J,Wu F,Tan L,Shi YG,Shi Y,Shen H

Mon Mar 01 00:00:00 EST 2021

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Clinical and translational medicine

Bian X,Shi D,Xing K,Zhou H,Lu L,Yu D,Wu W

Mon Mar 01 00:00:00 EST 2021

Local translation in nuclear condensate amyloid bodies.

Proceedings of the National Academy of Sciences of the United States of America

Theodoridis PR,Bokros M,Marijan D,Balukoff NC,Wang D,Kirk CC,Budine TD,Goldsmith HD,Wang M,Audas TE,Lee S

Tue Feb 16 00:00:00 EST 2021

HBV-Induced Increased N6 Methyladenosine Modification of PTEN RNA Affects Innate Immunity and Contributes to HCC.

Hepatology (Baltimore, Md.)

Kim GW,Imam H,Khan M,Mir SA,Kim SJ,Yoon SK,Hur W,Siddiqui A

Mon Feb 01 00:00:00 EST 2021

Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li T,Zhuang Y,Yang W,Xie Y,Shang W,Su S,Dong X,Wu J,Jiang W,Zhou Y,Li Y,Zhou X,Zhang M,Lu Y,Pan Z

Mon Feb 01 00:00:00 EST 2021

Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Li T,Zhuang Y,Yang W,Xie Y,Shang W,Su S,Dong X,Wu J,Jiang W,Zhou Y,Li Y,Zhou X,Zhang M,Lu Y,Pan Z

Mon Feb 01 00:00:00 EST 2021

Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs.

Proceedings of the National Academy of Sciences of the United States of America

Kim GW,Siddiqui A

Tue Jan 19 00:00:00 EST 2021

Reprogramming of m⁶A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

RNA biology

Wang YJ,Yang B,Lai Q,Shi JF,Peng JY,Zhang Y,Hu KS,Li YQ,Peng JW,Yang ZZ,Li YT,Pan Y,Koeffler HP,Liao JY,Yin D

Fri Jan 01 00:00:00 EST 2021

EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.

Frontiers in cell and developmental biology

Qi B,Yang C,Zhu Z,Chen H

Tue Dec 29 00:00:00 EST 2020

Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m⁶A-Based Epitranscriptomic Mechanism.

Molecular therapy : the journal of the American Society of Gene Therapy

Liu X,Gonzalez G,Dai X,Miao W,Yuan J,Huang M,Bade D,Li L,Sun Y,Wang Y

Wed Dec 02 00:00:00 EST 2020

NADP modulates RNA m⁶A methylation and adipogenesis via enhancing FTO activity.

Nature chemical biology

Wang L,Song C,Wang N,Li S,Liu Q,Sun Z,Wang K,Yu SC,Yang Q

Tue Dec 01 00:00:00 EST 2020

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

bioRxiv : the preprint server for biology

Wang L,Muneer A,Xie L,Zhang F,Wu B,Mei L,Lenarcic EM,Feng EH,Song J,Xiong Y,Yu X,Wang C,Gheorghe C,Torralba K,Cook JG,Wan YY,Moorman NJ,Song H,Jin J,Chen X

Mon Nov 16 00:00:00 EST 2020

Analysis of METTL3 and METTL14 in hepatocellular carcinoma.

Aging

Liu X,Qin J,Gao T,Li C,Chen X,Zeng K,Xu M,He B,Pan B,Xu X,Pan Y,Sun H,Xu T,Wang S

Fri Nov 06 00:00:00 EST 2020

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.

Nucleic acids research

Wu Z,Shi Y,Lu M,Song M,Yu Z,Wang J,Wang S,Ren J,Yang YG,Liu GH,Zhang W,Ci W,Qu J

Wed Nov 04 00:00:00 EST 2020

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.

Nucleic acids research

Wu Z,Shi Y,Lu M,Song M,Yu Z,Wang J,Wang S,Ren J,Yang YG,Liu GH,Zhang W,Ci W,Qu J

Wed Nov 04 00:00:00 EST 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N⁶-methyladenosine methylation of Parp10 mRNA.

Nature cell biology

Gao XQ,Zhang YH,Liu F,Ponnusamy M,Zhao XM,Zhou LY,Zhai M,Liu CY,Li XM,Wang M,Shan C,Shan PP,Wang Y,Dong YH,Qian LL,Yu T,Ju J,Wang T,Wang K,Chen XZ,Wang YH,Zhang J,Li PF,Wang K

Sun Nov 01 00:00:00 EDT 2020

Comprehensive analysis of translation from overexpressed circular RNAs reveals pervasive translation from linear transcripts.

Nucleic acids research

Ho-Xuan H,Glažar P,Latini C,Heizler K,Haase J,Hett R,Anders M,Weichmann F,Bruckmann A,Van den Berg D,Hüttelmaier S,Rajewsky N,Hackl C,Meister G

Fri Oct 09 00:00:00 EDT 2020

Context-dependent functional compensation between Ythdf m⁶A reader proteins.

Genes & development

Lasman L,Krupalnik V,Viukov S,Mor N,Aguilera-Castrejon A,Schneir D,Bayerl J,Mizrahi O,Peles S,Tawil S,Sathe S,Nachshon A,Shani T,Zerbib M,Kilimnik I,Aigner S,Shankar A,Mueller JR,Schwartz S,Stern-Ginossar N,Yeo GW,Geula S,Novershtern N,Hanna JH

Thu Oct 01 00:00:00 EDT 2020

METTL3 potentiates resistance to cisplatin through m⁶ A modification of TFAP2C in seminoma.

Journal of cellular and molecular medicine

Wei J,Yin Y,Zhou J,Chen H,Peng J,Yang J,Tang Y

Thu Oct 01 00:00:00 EDT 2020

Validation strategies for antibodies targeting modified ribonucleotides.

RNA (New York, N.Y.)

Weichmann F,Hett R,Schepers A,Ito-Kureha T,Flatley A,Slama K,Hastert FD,Angstman NB,Cardoso MC,König J,Hüttelmaier S,Dieterich C,Canzar S,Helm M,Heissmeyer V,Feederle R,Meister G

Thu Oct 01 00:00:00 EDT 2020

Methyltransferase 3 Mediated miRNA m6A Methylation Promotes Stress Granule Formation in the Early Stage of Acute Ischemic Stroke.

Frontiers in molecular neuroscience

Si W,Li Y,Ye S,Li Z,Liu Y,Kuang W,Chen D,Zhu M

Mon Sep 28 00:00:00 EDT 2020

m⁶A RNA Methylation Regulators Contribute to Eutopic Endometrium and Myometrium Dysfunction in Adenomyosis.

Frontiers in genetics

Zhai J,Li S,Sen S,Opoku-Anane J,Du Y,Chen ZJ,Giudice LC

Mon Sep 28 00:00:00 EDT 2020

m⁶A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis.

Frontiers in oncology

He JJ,Li Z,Rong ZX,Gao J,Mu Y,Guan YD,Ren XX,Zi YY,Liu LY,Fan Q,Zhou M,Duan YM,Zhou Q,Deng YZ,Sun LQ

Mon Sep 28 00:00:00 EDT 2020

The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.

Journal of Cancer

Yuan Y,Du Y,Wang L,Liu X

Mon Sep 28 00:00:00 EDT 2020

The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.

Journal of Cancer

Yuan Y,Du Y,Wang L,Liu X

Mon Sep 28 00:00:00 EDT 2020

N⁶-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling.

The Journal of biological chemistry

Kim GW,Imam H,Khan M,Siddiqui A

Fri Sep 11 00:00:00 EDT 2020

Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.

Oncology letters

Jiang L,Chen T,Xiong L,Xu JH,Gong AY,Dai B,Wu G,Zhu K,Lu E,Mathy NW,Chen XM

Tue Sep 01 00:00:00 EDT 2020

m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.

Oncology reports

Xu J,Chen Q,Tian K,Liang R,Chen T,Gong A,Mathy NW,Yu T,Chen X

Tue Sep 01 00:00:00 EDT 2020

Epitranscriptomic N⁶-Methyladenosine Modification Is Required for Direct Lineage Reprogramming into Neurons.

ACS chemical biology

Choi H,Baek S,Cho B,Kim S,Kim J,Chang Y,Shin J,Kim J

Fri Aug 21 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

m⁶A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Diabetes

Wang Y,Sun J,Lin Z,Zhang W,Wang S,Wang W,Wang Q,Ning G

Sat Aug 01 00:00:00 EDT 2020

Interplay of m⁶A and H3K27 trimethylation restrains inflammation during bacterial infection.

Science advances

Wu C,Chen W,He J,Jin S,Liu Y,Yi Y,Gao Z,Yang J,Yang J,Cui J,Zhao W

Sat Aug 01 00:00:00 EDT 2020

YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation.

Carcinogenesis

Sheng H,Li Z,Su S,Sun W,Zhang X,Li L,Li J,Liu S,Lu B,Zhang S,Shan C

Fri Jul 10 00:00:00 EDT 2020

Dynamic landscape and evolution of m6A methylation in human.

Nucleic acids research

Zhang H,Shi X,Huang T,Zhao X,Chen W,Gu N,Zhang R

Fri Jun 19 00:00:00 EDT 2020

ANKLE1 N⁶ -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.

International journal of cancer

Tian J,Ying P,Ke J,Zhu Y,Yang Y,Gong Y,Zou D,Peng X,Yang N,Wang X,Mei S,Zhang Y,Wang C,Zhong R,Chang J,Miao X

Mon Jun 15 00:00:00 EDT 2020

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhou L,Yang C,Zhang N,Zhang X,Zhao T,Yu J

Fri May 01 00:00:00 EDT 2020

Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhou L,Yang C,Zhang N,Zhang X,Zhao T,Yu J

Fri May 01 00:00:00 EDT 2020

Long noncoding RNA pncRNA-D reduces cyclin D1 gene expression and arrests cell cycle through RNA m⁶A modification.

The Journal of biological chemistry

Yoneda R,Ueda N,Uranishi K,Hirasaki M,Kurokawa R

Fri Apr 24 00:00:00 EDT 2020

N⁶-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I.

Nature microbiology

Lu M,Zhang Z,Xue M,Zhao BS,Harder O,Li A,Liang X,Gao TZ,Xu Y,Zhou J,Feng Z,Niewiesk S,Peeples ME,He C,Li J

Wed Apr 01 00:00:00 EDT 2020

METTL3 Modulates Osteoclast Differentiation and Function by Controlling RNA Stability and Nuclear Export.

International journal of molecular sciences

Li D,Cai L,Meng R,Feng Z,Xu Q

Fri Feb 28 00:00:00 EST 2020

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Zhang Y,Liu X,Liu L,Li J,Hu Q,Sun R

Sat Feb 22 00:00:00 EST 2020

Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts.

PLoS pathogens

Imam H,Kim GW,Mir SA,Khan M,Siddiqui A

Sat Feb 01 00:00:00 EST 2020

Direct RNA sequencing enables m⁶A detection in endogenous transcript isoforms at base-specific resolution.

RNA (New York, N.Y.)

Lorenz DA,Sathe S,Einstein JM,Yeo GW

Wed Jan 01 00:00:00 EST 2020

The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.

Molecular and cellular biochemistry

Yu J,Shen L,Liu Y,Ming H,Zhu X,Chu M,Lin J

Wed Jan 01 00:00:00 EST 2020

METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling.

International journal of molecular sciences

Zhang Y,Gu X,Li D,Cai L,Xu Q

Fri Dec 27 00:00:00 EST 2019

Resveratrol and Curcumin Improve Intestinal Mucosal Integrity and Decrease m⁶A RNA Methylation in the Intestine of Weaning Piglets.

ACS omega

Gan Z,Wei W,Wu J,Zhao Y,Zhang L,Wang T,Zhong X

Tue Oct 22 00:00:00 EDT 2019

Viral N⁶-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.

Nature communications

Xue M,Zhao BS,Zhang Z,Lu M,Harder O,Chen P,Lu Z,Li A,Ma Y,Xu Y,Liang X,Zhou J,Niewiesk S,Peeples ME,He C,Li J

Wed Oct 09 00:00:00 EDT 2019

Regulation of Co-transcriptional Pre-mRNA Splicing by m⁶A through the Low-Complexity Protein hnRNPG.

Molecular cell

Zhou KI,Shi H,Lyu R,Wylder AC,Matuszek Ż,Pan JN,He C,Parisien M,Pan T

Thu Oct 03 00:00:00 EDT 2019

Programmable RNA N⁶-methyladenosine editing by CRISPR-Cas9 conjugates.

Nature chemical biology

Liu XM,Zhou J,Mao Y,Ji Q,Qian SB

Sun Sep 01 00:00:00 EDT 2019

m⁶A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment.

Cell reports

Cheng Y,Luo H,Izzo F,Pickering BF,Nguyen D,Myers R,Schurer A,Gourkanti S,Brüning JC,Vu LP,Jaffrey SR,Landau DA,Kharas MG

Tue Aug 13 00:00:00 EDT 2019

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N⁶-methyladenosine.

Nature communications

Miao W,Li L,Zhao Y,Dai X,Chen X,Wang Y

Fri Aug 09 00:00:00 EDT 2019

METTL3 and ALKBH5 oppositely regulate m⁶A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes.

Autophagy

Song H,Feng X,Zhang H,Luo Y,Huang J,Lin M,Jin J,Ding X,Wu S,Huang H,Yu T,Zhang M,Hong H,Yao S,Zhao Y,Zhang Z

Thu Aug 01 00:00:00 EDT 2019

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma.

Oncogene

Green NH,Galvan DL,Badal SS,Chang BH,LeBleu VS,Long J,Jonasch E,Danesh FR

Thu Aug 01 00:00:00 EDT 2019

m⁶A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.

Nature communications

Yang S,Wei J,Cui YH,Park G,Shah P,Deng Y,Aplin AE,Lu Z,Hwang S,He C,He YY

Tue Jun 25 00:00:00 EDT 2019

Dynamic m⁶A mRNA methylation reveals the role of METTL3-m⁶A-CDCP1 signaling axis in chemical carcinogenesis.

Oncogene

Yang F,Jin H,Que B,Chao Y,Zhang H,Ying X,Zhou Z,Yuan Z,Su J,Wu B,Zhang W,Qi D,Chen D,Min W,Lin S,Ji W

Sat Jun 01 00:00:00 EDT 2019

Dynamic m⁶A mRNA methylation reveals the role of METTL3-m⁶A-CDCP1 signaling axis in chemical carcinogenesis.

Oncogene

Yang F,Jin H,Que B,Chao Y,Zhang H,Ying X,Zhou Z,Yuan Z,Su J,Wu B,Zhang W,Qi D,Chen D,Min W,Lin S,Ji W

Sat Jun 01 00:00:00 EDT 2019

Endoribonucleolytic Cleavage of m⁶A-Containing RNAs by RNase P/MRP Complex.

Molecular cell

Park OH,Ha H,Lee Y,Boo SH,Kwon DH,Song HK,Kim YK

Thu May 02 00:00:00 EDT 2019

Mettl3-mediated mRNA m⁶A methylation promotes dendritic cell activation.

Nature communications

Wang H,Hu X,Huang M,Liu J,Gu Y,Ma L,Zhou Q,Cao X

Tue Apr 23 00:00:00 EDT 2019

m⁶A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.

Genomics, proteomics & bioinformatics

Chen J,Zhang YC,Huang C,Shen H,Sun B,Cheng X,Zhang YJ,Yang YG,Shu Q,Yang Y,Li X

Mon Apr 01 00:00:00 EDT 2019

m⁶A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.

Genomics, proteomics & bioinformatics

Chen J,Zhang YC,Huang C,Shen H,Sun B,Cheng X,Zhang YJ,Yang YG,Shu Q,Yang Y,Li X

Mon Apr 01 00:00:00 EDT 2019

HIV-1 envelope proteins up-regulate N ⁶-methyladenosine levels of cellular RNA independently of viral replication.

The Journal of biological chemistry

Tirumuru N,Wu L

Fri Mar 01 00:00:00 EST 2019

HIV-1 envelope proteins up-regulate N ⁶-methyladenosine levels of cellular RNA independently of viral replication.

The Journal of biological chemistry

Tirumuru N,Wu L

Fri Mar 01 00:00:00 EST 2019

m⁶A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.

Cell death & disease

Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

Wed Feb 20 00:00:00 EST 2019

m⁶A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.

Cell death & disease

Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

Wed Feb 20 00:00:00 EST 2019

m⁶A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner.

Cell death & disease

Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Wang F,Wang Y,Wang X

Wed Feb 20 00:00:00 EST 2019

m⁶A modification controls the innate immune response to infection by targeting type I interferons.

Nature immunology

Winkler R,Gillis E,Lasman L,Safra M,Geula S,Soyris C,Nachshon A,Tai-Schmiedel J,Friedman N,Le-Trilling VTK,Trilling M,Mandelboim M,Hanna JH,Schwartz S,Stern-Ginossar N

Fri Feb 01 00:00:00 EST 2019

m⁶A modification controls the innate immune response to infection by targeting type I interferons.

Nature immunology

Winkler R,Gillis E,Lasman L,Safra M,Geula S,Soyris C,Nachshon A,Tai-Schmiedel J,Friedman N,Le-Trilling VTK,Trilling M,Mandelboim M,Hanna JH,Schwartz S,Stern-Ginossar N

Fri Feb 01 00:00:00 EST 2019

m⁶A modification controls the innate immune response to infection by targeting type I interferons.

Nature immunology

Winkler R,Gillis E,Lasman L,Safra M,Geula S,Soyris C,Nachshon A,Tai-Schmiedel J,Friedman N,Le-Trilling VTK,Trilling M,Mandelboim M,Hanna JH,Schwartz S,Stern-Ginossar N

Fri Feb 01 00:00:00 EST 2019

Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells.

International journal of molecular sciences

Tian C,Huang Y,Li Q,Feng Z,Xu Q

Mon Jan 28 00:00:00 EST 2019

Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.

Journal of immunology (Baltimore, Md. : 1950)

Zong X,Zhao J,Wang H,Lu Z,Wang F,Du H,Wang Y

Tue Jan 15 00:00:00 EST 2019

Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.

Journal of immunology (Baltimore, Md. : 1950)

Zong X,Zhao J,Wang H,Lu Z,Wang F,Du H,Wang Y

Tue Jan 15 00:00:00 EST 2019

N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.

Nucleic acids research

Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W

Thu Jan 10 00:00:00 EST 2019

N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.

Nucleic acids research

Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W

Thu Jan 10 00:00:00 EST 2019

N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.

Nucleic acids research

Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W

Thu Jan 10 00:00:00 EST 2019

N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.

Nucleic acids research

Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W

Thu Jan 10 00:00:00 EST 2019

RNA m⁶ A modification enzymes shape innate responses to DNA by regulating interferon β.

Genes & development

Rubio RM,Depledge DP,Bianco C,Thompson L,Mohr I

Sat Dec 01 00:00:00 EST 2018

RNA m⁶ A modification enzymes shape innate responses to DNA by regulating interferon β.

Genes & development

Rubio RM,Depledge DP,Bianco C,Thompson L,Mohr I

Sat Dec 01 00:00:00 EST 2018

Mettl3-mediated m⁶A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.

Nature communications

Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q

Wed Nov 14 00:00:00 EST 2018

Mettl3-mediated m⁶A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.

Nature communications

Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q

Wed Nov 14 00:00:00 EST 2018

Mettl3-mediated m⁶A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.

Nature communications

Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q

Wed Nov 14 00:00:00 EST 2018

Mettl3-mediated m⁶A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.

Nature communications

Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q

Wed Nov 14 00:00:00 EST 2018

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m⁶A mRNA Methylation.

Cell reports

Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V

Tue Nov 13 00:00:00 EST 2018

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m⁶A mRNA Methylation.

Cell reports

Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V

Tue Nov 13 00:00:00 EST 2018

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m⁶A mRNA Methylation.

Cell reports

Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V

Tue Nov 13 00:00:00 EST 2018

mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

International journal of obesity (2005)

Wang X,Sun B,Jiang Q,Wu R,Cai M,Yao Y,Liu Q,Shi H,Feng J,Wang Y

Thu Nov 01 00:00:00 EDT 2018

mRNA m⁶A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.

International journal of obesity (2005)

Wang X,Sun B,Jiang Q,Wu R,Cai M,Yao Y,Liu Q,Shi H,Feng J,Wang Y

Thu Nov 01 00:00:00 EDT 2018

A dynamic N⁶-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.

Cell research

Yan F,Al-Kali A,Zhang Z,Liu J,Pang J,Zhao N,He C,Litzow MR,Liu S

Thu Nov 01 00:00:00 EDT 2018

A dynamic N⁶-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.

Cell research

Yan F,Al-Kali A,Zhang Z,Liu J,Pang J,Zhao N,He C,Litzow MR,Liu S

Thu Nov 01 00:00:00 EDT 2018

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.

Gynecologic oncology

Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P

Thu Nov 01 00:00:00 EDT 2018

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.

Gynecologic oncology

Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P

Thu Nov 01 00:00:00 EDT 2018

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.

Gynecologic oncology

Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P

Thu Nov 01 00:00:00 EDT 2018

METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.

Gynecologic oncology

Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P

Thu Nov 01 00:00:00 EDT 2018

The m⁶A-methylase complex recruits TREX and regulates mRNA export.

Scientific reports

Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SA

Fri Sep 14 00:00:00 EDT 2018

The m⁶A-methylase complex recruits TREX and regulates mRNA export.

Scientific reports

Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SA

Fri Sep 14 00:00:00 EDT 2018

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nature cell biology

Liu J,Eckert MA,Harada BT,Liu SM,Lu Z,Yu K,Tienda SM,Chryplewicz A,Zhu AC,Yang Y,Huang JT,Chen SM,Xu ZG,Leng XH,Yu XC,Cao J,Zhang Z,Liu J,Lengyel E,He C

Sat Sep 01 00:00:00 EDT 2018

m⁶A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nature cell biology

Liu J,Eckert MA,Harada BT,Liu SM,Lu Z,Yu K,Tienda SM,Chryplewicz A,Zhu AC,Yang Y,Huang JT,Chen SM,Xu ZG,Leng XH,Yu XC,Cao J,Zhang Z,Liu J,Lengyel E,He C

Sat Sep 01 00:00:00 EDT 2018

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.

Nature

Choe J,Lin S,Zhang W,Liu Q,Wang L,Ramirez-Moya J,Du P,Kim W,Tang S,Sliz P,Santisteban P,George RE,Richards WG,Wong KK,Locker N,Slack FJ,Gregory RI

Sat Sep 01 00:00:00 EDT 2018

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.

Nature

Choe J,Lin S,Zhang W,Liu Q,Wang L,Ramirez-Moya J,Du P,Kim W,Tang S,Sliz P,Santisteban P,George RE,Richards WG,Wong KK,Locker N,Slack FJ,Gregory RI

Sat Sep 01 00:00:00 EDT 2018

The Role of m⁶A/m-RNA Methylation in Stress Response Regulation.

Neuron

Engel M,Eggert C,Kaplick PM,Eder M,Röh S,Tietze L,Namendorf C,Arloth J,Weber P,Rex-Haffner M,Geula S,Jakovcevski M,Hanna JH,Leshkowitz D,Uhr M,Wotjak CT,Schmidt MV,Deussing JM,Binder EB,Chen A

Wed Jul 25 00:00:00 EDT 2018

The Role of m⁶A/m-RNA Methylation in Stress Response Regulation.

Neuron

Engel M,Eggert C,Kaplick PM,Eder M,Röh S,Tietze L,Namendorf C,Arloth J,Weber P,Rex-Haffner M,Geula S,Jakovcevski M,Hanna JH,Leshkowitz D,Uhr M,Wotjak CT,Schmidt MV,Deussing JM,Binder EB,Chen A

Wed Jul 25 00:00:00 EDT 2018

Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency.

Cell reports

Louloupi A,Ntini E,Conrad T,Ørom UAV

Tue Jun 19 00:00:00 EDT 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 EDT 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 EDT 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 EDT 2018

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Nucleic acids research

Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J

Fri Jun 01 00:00:00 EDT 2018

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.

Journal of cellular and molecular medicine

Feng Z,Li Q,Meng R,Yi B,Xu Q

Tue May 01 00:00:00 EDT 2018

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.

Journal of cellular and molecular medicine

Feng Z,Li Q,Meng R,Yi B,Xu Q

Tue May 01 00:00:00 EDT 2018

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m⁶A machinery component Wtap/Fl(2)d.

Genes & development

Knuckles P,Lence T,Haussmann IU,Jacob D,Kreim N,Carl SH,Masiello I,Hares T,Villaseñor R,Hess D,Andrade-Navarro MA,Biggiogera M,Helm M,Soller M,Bühler M,Roignant JY

Thu Mar 01 00:00:00 EST 2018

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m⁶A machinery component Wtap/Fl(2)d.

Genes & development

Knuckles P,Lence T,Haussmann IU,Jacob D,Kreim N,Carl SH,Masiello I,Hares T,Villaseñor R,Hess D,Andrade-Navarro MA,Biggiogera M,Helm M,Soller M,Bühler M,Roignant JY

Thu Mar 01 00:00:00 EST 2018

Dynamic m6A modification regulates local translation of mRNA in axons.

Nucleic acids research

Yu J,Chen M,Huang H,Zhu J,Song H,Zhu J,Park J,Ji SJ

Fri Feb 16 00:00:00 EST 2018

Dynamic m6A modification regulates local translation of mRNA in axons.

Nucleic acids research

Yu J,Chen M,Huang H,Zhu J,Song H,Zhu J,Park J,Ji SJ

Fri Feb 16 00:00:00 EST 2018

N⁶-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Molecular cell

Zhou J,Wan J,Shu XE,Mao Y,Liu XM,Yuan X,Zhang X,Hess ME,Brüning JC,Qian SB

Thu Feb 15 00:00:00 EST 2018

N⁶-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.

Molecular cell

Zhou J,Wan J,Shu XE,Mao Y,Liu XM,Yuan X,Zhang X,Hess ME,Brüning JC,Qian SB

Thu Feb 15 00:00:00 EST 2018

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

International journal of oncology

Taketo K,Konno M,Asai A,Koseki J,Toratani M,Satoh T,Doki Y,Mori M,Ishii H,Ogawa K

Thu Feb 01 00:00:00 EST 2018

The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.

International journal of oncology

Taketo K,Konno M,Asai A,Koseki J,Toratani M,Satoh T,Doki Y,Mori M,Ishii H,Ogawa K

Thu Feb 01 00:00:00 EST 2018

Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.

Genetics

Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W

Thu Feb 01 00:00:00 EST 2018

Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.

Genetics

Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W

Thu Feb 01 00:00:00 EST 2018

Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.

Genetics

Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W

Thu Feb 01 00:00:00 EST 2018

Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.

Genetics

Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W

Thu Feb 01 00:00:00 EST 2018

Thiol-linked alkylation of RNA to assess expression dynamics.

Nature methods

Herzog VA,Reichholf B,Neumann T,Rescheneder P,Bhat P,Burkard TR,Wlotzka W,von Haeseler A,Zuber J,Ameres SL

Fri Dec 01 00:00:00 EST 2017

Thiol-linked alkylation of RNA to assess expression dynamics.

Nature methods

Herzog VA,Reichholf B,Neumann T,Rescheneder P,Bhat P,Burkard TR,Wlotzka W,von Haeseler A,Zuber J,Ameres SL

Fri Dec 01 00:00:00 EST 2017

m⁶A Facilitates eIF4F-Independent mRNA Translation.

Molecular cell

Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB

Thu Nov 02 00:00:00 EDT 2017

m⁶A Facilitates eIF4F-Independent mRNA Translation.

Molecular cell

Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB

Thu Nov 02 00:00:00 EDT 2017

m⁶A Facilitates eIF4F-Independent mRNA Translation.

Molecular cell

Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB

Thu Nov 02 00:00:00 EDT 2017

m⁶A Facilitates eIF4F-Independent mRNA Translation.

Molecular cell

Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB

Thu Nov 02 00:00:00 EDT 2017

The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

Nature medicine

Vu LP,Pickering BF,Cheng Y,Zaccara S,Nguyen D,Minuesa G,Chou T,Chow A,Saletore Y,MacKay M,Schulman J,Famulare C,Patel M,Klimek VM,Garrett-Bakelman FE,Melnick A,Carroll M,Mason CE,Jaffrey SR,Kharas MG

Wed Nov 01 00:00:00 EDT 2017

The N⁶-methyladenosine (m⁶A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.

Nature medicine

Vu LP,Pickering BF,Cheng Y,Zaccara S,Nguyen D,Minuesa G,Chou T,Chow A,Saletore Y,MacKay M,Schulman J,Famulare C,Patel M,Klimek VM,Garrett-Bakelman FE,Melnick A,Carroll M,Mason CE,Jaffrey SR,Kharas MG

Wed Nov 01 00:00:00 EDT 2017

Region-specific RNA m⁶A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

Open biology

Chang M,Lv H,Zhang W,Ma C,He X,Zhao S,Zhang ZW,Zeng YX,Song S,Niu Y,Tong WM

Fri Sep 01 00:00:00 EDT 2017

Region-specific RNA m⁶A methylation represents a new layer of control in the gene regulatory network in the mouse brain.

Open biology

Chang M,Lv H,Zhang W,Ma C,He X,Zhao S,Zhang ZW,Zeng YX,Song S,Niu Y,Tong WM

Fri Sep 01 00:00:00 EDT 2017

The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.

Open biology

Kudou K,Komatsu T,Nogami J,Maehara K,Harada A,Saeki H,Oki E,Maehara Y,Ohkawa Y

Fri Sep 01 00:00:00 EDT 2017

The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.

Open biology

Kudou K,Komatsu T,Nogami J,Maehara K,Harada A,Saeki H,Oki E,Maehara Y,Ohkawa Y

Fri Sep 01 00:00:00 EDT 2017

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.

Journal of cellular biochemistry

Li Q,Li X,Tang H,Jiang B,Dou Y,Gorospe M,Wang W

Fri Sep 01 00:00:00 EDT 2017

NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.

Journal of cellular biochemistry

Li Q,Li X,Tang H,Jiang B,Dou Y,Gorospe M,Wang W

Fri Sep 01 00:00:00 EDT 2017

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.

Nature structural & molecular biology

Knuckles P,Carl SH,Musheev M,Niehrs C,Wenger A,Bühler M

Sat Jul 01 00:00:00 EDT 2017

RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.

Nature structural & molecular biology

Knuckles P,Carl SH,Musheev M,Niehrs C,Wenger A,Bühler M

Sat Jul 01 00:00:00 EDT 2017

N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.

Nucleic acids research

Liu N,Zhou KI,Parisien M,Dai Q,Diatchenko L,Pan T

Fri Jun 02 00:00:00 EDT 2017

N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.

Nucleic acids research

Liu N,Zhou KI,Parisien M,Dai Q,Diatchenko L,Pan T

Fri Jun 02 00:00:00 EDT 2017

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Cell

Slobodin B,Han R,Calderone V,Vrielink JAFO,Loayza-Puch F,Elkon R,Agami R

Thu Apr 06 00:00:00 EDT 2017

Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.

Cell

Slobodin B,Han R,Calderone V,Vrielink JAFO,Loayza-Puch F,Elkon R,Agami R

Thu Apr 06 00:00:00 EDT 2017

m⁶A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.

Cell reports

Cui Q,Shi H,Ye P,Li L,Qu Q,Sun G,Sun G,Lu Z,Huang Y,Yang CG,Riggs AD,He C,Shi Y

Tue Mar 14 00:00:00 EDT 2017

m⁶A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.

Cell reports

Cui Q,Shi H,Ye P,Li L,Qu Q,Sun G,Sun G,Lu Z,Huang Y,Yang CG,Riggs AD,He C,Shi Y

Tue Mar 14 00:00:00 EDT 2017

AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N⁶-methyladenosine.

Scientific reports

Wu W,Feng J,Jiang D,Zhou X,Jiang Q,Cai M,Wang X,Shan T,Wang Y

Wed Feb 08 00:00:00 EST 2017

AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N⁶-methyladenosine.

Scientific reports

Wu W,Feng J,Jiang D,Zhou X,Jiang Q,Cai M,Wang X,Shan T,Wang Y

Wed Feb 08 00:00:00 EST 2017

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

eLife

Tirumuru N,Zhao BS,Lu W,Lu Z,He C,Wu L

Sat Jul 02 00:00:00 EDT 2016

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

eLife

Tirumuru N,Zhao BS,Lu W,Lu Z,He C,Wu L

Sat Jul 02 00:00:00 EDT 2016

The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

Molecular cell

Lin S,Choe J,Du P,Triboulet R,Gregory RI

Thu May 05 00:00:00 EDT 2016

The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.

Molecular cell

Lin S,Choe J,Du P,Triboulet R,Gregory RI

Thu May 05 00:00:00 EDT 2016

m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.

Cell stem cell

Chen T,Hao YJ,Zhang Y,Li MM,Wang M,Han W,Wu Y,Lv Y,Hao J,Wang L,Li A,Yang Y,Jin KX,Zhao X,Li Y,Ping XL,Lai WY,Wu LG,Jiang G,Wang HL,Sang L,Wang XJ,Yang YG,Zhou Q

Thu Mar 05 00:00:00 EST 2015

m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.

Cell stem cell

Chen T,Hao YJ,Zhang Y,Li MM,Wang M,Han W,Wu Y,Lv Y,Hao J,Wang L,Li A,Yang Y,Jin KX,Zhao X,Li Y,Ping XL,Lai WY,Wu LG,Jiang G,Wang HL,Sang L,Wang XJ,Yang YG,Zhou Q

Thu Mar 05 00:00:00 EST 2015

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Science (New York, N.Y.)

Geula S,Moshitch-Moshkovitz S,Dominissini D,Mansour AA,Kol N,Salmon-Divon M,Hershkovitz V,Peer E,Mor N,Manor YS,Ben-Haim MS,Eyal E,Yunger S,Pinto Y,Jaitin DA,Viukov S,Rais Y,Krupalnik V,Chomsky E,Zerbib M,Maza I,Rechavi Y,Massarwa R,Hanna S,Amit I,Levanon EY,Amariglio N,Stern-Ginossar N,Novershtern N,Rechavi G,Hanna JH

Fri Feb 27 00:00:00 EST 2015

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Science (New York, N.Y.)

Fri Feb 27 00:00:00 EST 2015

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Science (New York, N.Y.)

Fri Feb 27 00:00:00 EST 2015

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.

Science (New York, N.Y.)

Fri Feb 27 00:00:00 EST 2015

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Cell stem cell

Batista PJ,Molinie B,Wang J,Qu K,Zhang J,Li L,Bouley DM,Lujan E,Haddad B,Daneshvar K,Carter AC,Flynn RA,Zhou C,Lim KS,Dedon P,Wernig M,Mullen AC,Xing Y,Giallourakis CC,Chang HY

Thu Dec 04 00:00:00 EST 2014

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Cell stem cell

Batista PJ,Molinie B,Wang J,Qu K,Zhang J,Li L,Bouley DM,Lujan E,Haddad B,Daneshvar K,Carter AC,Flynn RA,Zhou C,Lim KS,Dedon P,Wernig M,Mullen AC,Xing Y,Giallourakis CC,Chang HY

Thu Dec 04 00:00:00 EST 2014

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

Cell research

Zhao X,Yang Y,Sun BF,Shi Y,Yang X,Xiao W,Hao YJ,Ping XL,Chen YS,Wang WJ,Jin KX,Wang X,Huang CM,Fu Y,Ge XM,Song SH,Jeong HS,Yanagisawa H,Niu Y,Jia GF,Wu W,Tong WM,Okamoto A,He C,Rendtlew Danielsen JM,Wang XJ,Yang YG

Mon Dec 01 00:00:00 EST 2014

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.

Cell research

Mon Dec 01 00:00:00 EST 2014

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Nature chemical biology

Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C

Sat Feb 01 00:00:00 EST 2014

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Nature chemical biology

Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C

Sat Feb 01 00:00:00 EST 2014

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Nature chemical biology

Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C

Sat Feb 01 00:00:00 EST 2014

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Nature chemical biology

Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C

Sat Feb 01 00:00:00 EST 2014

N6-methyladenosine-dependent regulation of messenger RNA stability.

Nature

Wang X,Lu Z,Gomez A,Hon GC,Yue Y,Han D,Fu Y,Parisien M,Dai Q,Jia G,Ren B,Pan T,He C

Thu Jan 02 00:00:00 EST 2014

N6-methyladenosine-dependent regulation of messenger RNA stability.

Nature

Wang X,Lu Z,Gomez A,Hon GC,Yue Y,Han D,Fu Y,Parisien M,Dai Q,Jia G,Ren B,Pan T,He C

Thu Jan 02 00:00:00 EST 2014

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

Cell

Fustin JM,Doi M,Yamaguchi Y,Hida H,Nishimura S,Yoshida M,Isagawa T,Morioka MS,Kakeya H,Manabe I,Okamura H

Thu Nov 07 00:00:00 EST 2013

RNA-methylation-dependent RNA processing controls the speed of the circadian clock.

Cell

Fustin JM,Doi M,Yamaguchi Y,Hida H,Nishimura S,Yoshida M,Isagawa T,Morioka MS,Kakeya H,Manabe I,Okamura H

Thu Nov 07 00:00:00 EST 2013

Bioinformatics

Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; m6a methyltransferase; methyltransferase-like 3; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; N6-adenosine-methyltransferase subunit METTL3

Gene Aliases: 2310024F18Rik; IME4; M6A; METTL3; MT-A70; MTA70; Spo8

UniProt ID: (Human) Q86U44, (Mouse) Q8C3P7

Entrez Gene ID: (Human) 56339, (Mouse) 56335, (Rat) 361035

Molecular Function: RNA metabolism protein RNA methyltransferase nucleic acid metabolism protein