Product References
HIV-1 envelope proteins up-regulate N 6-methyladenosine levels of cellular RNA independently of viral replication.
The Journal of biological chemistry
Tirumuru N,Wu L
Fri Mar 01 00:00:00 EST 2019
m6A modification controls the innate immune response to infection by targeting type I interferons.
Nature immunology
Winkler R,Gillis E,Lasman L,Safra M,Geula S,Soyris C,Nachshon A,Tai-Schmiedel J,Friedman N,Le-Trilling VTK,Trilling M,Mandelboim M,Hanna JH,Schwartz S,Stern-Ginossar N
Fri Feb 01 00:00:00 EST 2019
m6A modification controls the innate immune response to infection by targeting type I interferons.
Nature immunology
Winkler R,Gillis E,Lasman L,Safra M,Geula S,Soyris C,Nachshon A,Tai-Schmiedel J,Friedman N,Le-Trilling VTK,Trilling M,Mandelboim M,Hanna JH,Schwartz S,Stern-Ginossar N
Fri Feb 01 00:00:00 EST 2019
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
Journal of immunology (Baltimore, Md. : 1950)
Zong X,Zhao J,Wang H,Lu Z,Wang F,Du H,Wang Y
Tue Jan 15 00:00:00 EST 2019
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Nucleic acids research
Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W
Thu Jan 10 00:00:00 EST 2019
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication.
Nucleic acids research
Hao H,Hao S,Chen H,Chen Z,Zhang Y,Wang J,Wang H,Zhang B,Qiu J,Deng F,Guan W
Thu Jan 10 00:00:00 EST 2019
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Genes & development
Rubio RM,Depledge DP,Bianco C,Thompson L,Mohr I
Sat Dec 01 00:00:00 EST 2018
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Nature communications
Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q
Wed Nov 14 00:00:00 EST 2018
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Nature communications
Wu Y,Xie L,Wang M,Xiong Q,Guo Y,Liang Y,Li J,Sheng R,Deng P,Wang Y,Zheng R,Jiang Y,Ye L,Chen Q,Zhou X,Lin S,Yuan Q
Wed Nov 14 00:00:00 EST 2018
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Cell reports
Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V
Tue Nov 13 00:00:00 EST 2018
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Cell reports
Zhong X,Yu J,Frazier K,Weng X,Li Y,Cham CM,Dolan K,Zhu X,Hubert N,Tao Y,Lin F,Martinez-Guryn K,Huang Y,Wang T,Liu J,He C,Chang EB,Leone V
Tue Nov 13 00:00:00 EST 2018
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Gynecologic oncology
Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P
Thu Nov 01 00:00:00 EDT 2018
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Gynecologic oncology
Hua W,Zhao Y,Jin X,Yu D,He J,Xie D,Duan P
Thu Nov 01 00:00:00 EDT 2018
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors.
Cell research
Yan F,Al-Kali A,Zhang Z,Liu J,Pang J,Zhao N,He C,Litzow MR,Liu S
Thu Nov 01 00:00:00 EDT 2018
mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes.
International journal of obesity (2005)
Wang X,Sun B,Jiang Q,Wu R,Cai M,Yao Y,Liu Q,Shi H,Feng J,Wang Y
Thu Nov 01 00:00:00 EDT 2018
The m6A-methylase complex recruits TREX and regulates mRNA export.
Scientific reports
Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SA
Fri Sep 14 00:00:00 EDT 2018
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.
Nature
Choe J,Lin S,Zhang W,Liu Q,Wang L,Ramirez-Moya J,Du P,Kim W,Tang S,Sliz P,Santisteban P,George RE,Richards WG,Wong KK,Locker N,Slack FJ,Gregory RI
Sat Sep 01 00:00:00 EDT 2018
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Nature cell biology
Liu J,Eckert MA,Harada BT,Liu SM,Lu Z,Yu K,Tienda SM,Chryplewicz A,Zhu AC,Yang Y,Huang JT,Chen SM,Xu ZG,Leng XH,Yu XC,Cao J,Zhang Z,Liu J,Lengyel E,He C
Sat Sep 01 00:00:00 EDT 2018
The Role of m6A/m-RNA Methylation in Stress Response Regulation.
Neuron
Engel M,Eggert C,Kaplick PM,Eder M,Röh S,Tietze L,Namendorf C,Arloth J,Weber P,Rex-Haffner M,Geula S,Jakovcevski M,Hanna JH,Leshkowitz D,Uhr M,Wotjak CT,Schmidt MV,Deussing JM,Binder EB,Chen A
Wed Jul 25 00:00:00 EDT 2018
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Nucleic acids research
Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J
Fri Jun 01 00:00:00 EDT 2018
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.
Nucleic acids research
Du Y,Hou G,Zhang H,Dou J,He J,Guo Y,Li L,Chen R,Wang Y,Deng R,Huang J,Jiang B,Xu M,Cheng J,Chen GQ,Zhao X,Yu J
Fri Jun 01 00:00:00 EDT 2018
METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells.
Journal of cellular and molecular medicine
Feng Z,Li Q,Meng R,Yi B,Xu Q
Tue May 01 00:00:00 EDT 2018
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.
Genes & development
Knuckles P,Lence T,Haussmann IU,Jacob D,Kreim N,Carl SH,Masiello I,Hares T,Villaseñor R,Hess D,Andrade-Navarro MA,Biggiogera M,Helm M,Soller M,Bühler M,Roignant JY
Thu Mar 01 00:00:00 EST 2018
Dynamic m6A modification regulates local translation of mRNA in axons.
Nucleic acids research
Yu J,Chen M,Huang H,Zhu J,Song H,Zhu J,Park J,Ji SJ
Fri Feb 16 00:00:00 EST 2018
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Molecular cell
Zhou J,Wan J,Shu XE,Mao Y,Liu XM,Yuan X,Zhang X,Hess ME,Brüning JC,Qian SB
Thu Feb 15 00:00:00 EST 2018
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells.
International journal of oncology
Taketo K,Konno M,Asai A,Koseki J,Toratani M,Satoh T,Doki Y,Mori M,Ishii H,Ogawa K
Thu Feb 01 00:00:00 EST 2018
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Genetics
Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W
Thu Feb 01 00:00:00 EST 2018
Mettl3 Mutation Disrupts Gamete Maturation and Reduces Fertility in Zebrafish.
Genetics
Xia H,Zhong C,Wu X,Chen J,Tao B,Xia X,Shi M,Zhu Z,Trudeau VL,Hu W
Thu Feb 01 00:00:00 EST 2018
Thiol-linked alkylation of RNA to assess expression dynamics.
Nature methods
Herzog VA,Reichholf B,Neumann T,Rescheneder P,Bhat P,Burkard TR,Wlotzka W,von Haeseler A,Zuber J,Ameres SL
Fri Dec 01 00:00:00 EST 2017
m6A Facilitates eIF4F-Independent mRNA Translation.
Molecular cell
Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB
Thu Nov 02 00:00:00 EDT 2017
m6A Facilitates eIF4F-Independent mRNA Translation.
Molecular cell
Coots RA,Liu XM,Mao Y,Dong L,Zhou J,Wan J,Zhang X,Qian SB
Thu Nov 02 00:00:00 EDT 2017
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.
Nature medicine
Vu LP,Pickering BF,Cheng Y,Zaccara S,Nguyen D,Minuesa G,Chou T,Chow A,Saletore Y,MacKay M,Schulman J,Famulare C,Patel M,Klimek VM,Garrett-Bakelman FE,Melnick A,Carroll M,Mason CE,Jaffrey SR,Kharas MG
Wed Nov 01 00:00:00 EDT 2017
Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain.
Open biology
Chang M,Lv H,Zhang W,Ma C,He X,Zhao S,Zhang ZW,Zeng YX,Song S,Niu Y,Tong WM
Fri Sep 01 00:00:00 EDT 2017
The requirement of Mettl3-promoted MyoD mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation.
Open biology
Kudou K,Komatsu T,Nogami J,Maehara K,Harada A,Saeki H,Oki E,Maehara Y,Ohkawa Y
Fri Sep 01 00:00:00 EDT 2017
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
Journal of cellular biochemistry
Li Q,Li X,Tang H,Jiang B,Dou Y,Gorospe M,Wang W
Fri Sep 01 00:00:00 EDT 2017
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
Nature structural & molecular biology
Knuckles P,Carl SH,Musheev M,Niehrs C,Wenger A,Bühler M
Sat Jul 01 00:00:00 EDT 2017
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein.
Nucleic acids research
Liu N,Zhou KI,Parisien M,Dai Q,Diatchenko L,Pan T
Fri Jun 02 00:00:00 EDT 2017
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
Cell
Slobodin B,Han R,Calderone V,Vrielink JAFO,Loayza-Puch F,Elkon R,Agami R
Thu Apr 06 00:00:00 EDT 2017
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.
Cell reports
Cui Q,Shi H,Ye P,Li L,Qu Q,Sun G,Sun G,Lu Z,Huang Y,Yang CG,Riggs AD,He C,Shi Y
Tue Mar 14 00:00:00 EDT 2017
AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine.
Scientific reports
Wu W,Feng J,Jiang D,Zhou X,Jiang Q,Cai M,Wang X,Shan T,Wang Y
Wed Feb 08 00:00:00 EST 2017
N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.
eLife
Tirumuru N,Zhao BS,Lu W,Lu Z,He C,Wu L
Sat Jul 02 00:00:00 EDT 2016
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells.
Molecular cell
Lin S,Choe J,Du P,Triboulet R,Gregory RI
Thu May 05 00:00:00 EDT 2016
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
Cell stem cell
Chen T,Hao YJ,Zhang Y,Li MM,Wang M,Han W,Wu Y,Lv Y,Hao J,Wang L,Li A,Yang Y,Jin KX,Zhao X,Li Y,Ping XL,Lai WY,Wu LG,Jiang G,Wang HL,Sang L,Wang XJ,Yang YG,Zhou Q
Thu Mar 05 00:00:00 EST 2015
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Science (New York, N.Y.)
Geula S,Moshitch-Moshkovitz S,Dominissini D,Mansour AA,Kol N,Salmon-Divon M,Hershkovitz V,Peer E,Mor N,Manor YS,Ben-Haim MS,Eyal E,Yunger S,Pinto Y,Jaitin DA,Viukov S,Rais Y,Krupalnik V,Chomsky E,Zerbib M,Maza I,Rechavi Y,Massarwa R,Hanna S,Amit I,Levanon EY,Amariglio N,Stern-Ginossar N,Novershtern N,Rechavi G,Hanna JH
Fri Feb 27 00:00:00 EST 2015
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Science (New York, N.Y.)
Geula S,Moshitch-Moshkovitz S,Dominissini D,Mansour AA,Kol N,Salmon-Divon M,Hershkovitz V,Peer E,Mor N,Manor YS,Ben-Haim MS,Eyal E,Yunger S,Pinto Y,Jaitin DA,Viukov S,Rais Y,Krupalnik V,Chomsky E,Zerbib M,Maza I,Rechavi Y,Massarwa R,Hanna S,Amit I,Levanon EY,Amariglio N,Stern-Ginossar N,Novershtern N,Rechavi G,Hanna JH
Fri Feb 27 00:00:00 EST 2015
m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.
Cell stem cell
Batista PJ,Molinie B,Wang J,Qu K,Zhang J,Li L,Bouley DM,Lujan E,Haddad B,Daneshvar K,Carter AC,Flynn RA,Zhou C,Lim KS,Dedon P,Wernig M,Mullen AC,Xing Y,Giallourakis CC,Chang HY
Thu Dec 04 00:00:00 EST 2014
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Cell research
Zhao X,Yang Y,Sun BF,Shi Y,Yang X,Xiao W,Hao YJ,Ping XL,Chen YS,Wang WJ,Jin KX,Wang X,Huang CM,Fu Y,Ge XM,Song SH,Jeong HS,Yanagisawa H,Niu Y,Jia GF,Wu W,Tong WM,Okamoto A,He C,Rendtlew Danielsen JM,Wang XJ,Yang YG
Mon Dec 01 00:00:00 EST 2014
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Nature chemical biology
Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C
Sat Feb 01 00:00:00 EST 2014
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Nature chemical biology
Liu J,Yue Y,Han D,Wang X,Fu Y,Zhang L,Jia G,Yu M,Lu Z,Deng X,Dai Q,Chen W,He C
Sat Feb 01 00:00:00 EST 2014
N6-methyladenosine-dependent regulation of messenger RNA stability.
Nature
Wang X,Lu Z,Gomez A,Hon GC,Yue Y,Han D,Fu Y,Parisien M,Dai Q,Jia G,Ren B,Pan T,He C
Thu Jan 02 00:00:00 EST 2014
RNA-methylation-dependent RNA processing controls the speed of the circadian clock.
Cell
Fustin JM,Doi M,Yamaguchi Y,Hida H,Nishimura S,Yoshida M,Isagawa T,Morioka MS,Kakeya H,Manabe I,Okamura H
Thu Nov 07 00:00:00 EST 2013