Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (80%), Xenopus laevis (81%), Chimpanzee (100%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
METTL3 is the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; hMETTL3; IME4; M6A; Methyltransferase-like protein 3; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; MT-A70; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit; Spo8
Gene Aliases: IME4; M6A; METTL3; MT-A70; MTA70; Spo8
UniProt ID: (Human) Q86U44
Entrez Gene ID: (Human) 56339