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Proteintech
MEX3C Polyclonal Antibody
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Product Details
22882-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEX3C Fusion Protein Ag18931 (265-415 aa encoded by BC148855)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Amount
22.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GSNRLADFS PTSPFSTGNF WFGDTLPSVG SEDLAVDSPA FDSLPTSAQT IWTPFEPVNP LSGFGSDPSG NMKTQRRGSQ PSTPRLSPTF PESIEHPLAR RVRSDPPSTG NHVGLPIYIP AFSNGTNSYS SSNGGSTSSS PPESRRKHDC VI (265-415 aa encoded by BC148855)
Target Information
Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mex-3 homolog C; MEX3C variant 1; MEX3C variant 10; MEX3C variant 11; MEX3C variant 2; MEX3C variant 3; MEX3C variant 4; MEX3C variant 5; MEX3C variant 6; MEX3C variant 9; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein; RNA-binding protein MEX3C; unnamed protein product
Gene Aliases: A130001D14Rik; BC035207; BM-013; MEX-3C; MEX3C; RKHD2; RNF194
UniProt ID: (Human) Q5U5Q3, (Mouse) Q05A36
Entrez Gene ID: (Human) 51320, (Mouse) 240396, (Rat) 307271
nucleic acid binding
RNA binding
protein binding
zinc ion binding
transferase activity
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
poly(A) RNA binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
RNA metabolism protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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