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Invitrogen
MFN1 Polyclonal Antibody
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Product Details
PA5-97281
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 622-741 of human Mitofusin-1/MFN1 (NP_2849412)
Conjugate
Form
Liquid
Concentration
3.78 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: A-549, LO2, SW480, Mouse liver, Mouse kidney; Cellular Location: Cytoplasm, Mitochondrion outer membrane, Multi-pass membrane protein
Immunogen sequence: YGALYLYERL SWTTHAKERA FKQQFVNYAT EKLRMIVSST SANCSHQVKQ QIATTFARLC QQVDITQKQL EEEIARLPKE IDQLEKIQNN SKLLRNKAVQ LENELENFTK QFLPSSNEES
Target Information
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development. When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp762F247; EC 3.6.5; FLJ20693; Fzo homolog; MFN1; putative mitochondrial transmembrane GTPase; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitochondrial transmembrane GTPase FZO1B; Mitofusin-1; putative transmembrane GTPase; similar to Drosophila fuzzy onions encoded by GenBank Accession Number U95821; Transmembrane GTPase MFN1; unnamed protein product
Gene Aliases: 2310002F04Rik; 6330416C07Rik; D3Ertd265e; Fzo1b; hfzo1; hfzo2; HR2; MFN1; mKIAA4032
UniProt ID: (Human) Q8IWA4, (Rat) Q8R4Z9, (Mouse) Q811U4
Entrez Gene ID: (Human) 55669, (Rat) 192647, (Mouse) 67414
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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