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Proteintech
MFN2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
12186-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MFN2 Fusion Protein Ag2845 (2-353 aa encoded by BC017061)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLLFSRCNS IVTVKKNKRH MAEVNASPLK HFVTAKKKIN GIFEQLGAYI QESATFLEDT YRNAELDPVT TEEQVLDVKG YLSKVRGISE VLARRHMKVA FFGRTSNGKS TVINAMLWDK VLPSGIGHTT NCFLRVEGTD GHEAFLLTEG SEEKRSAKTV NQLAHALHQD KQLHAGSLVS VMWPNSKCPL LKDDLVLMDS PGIDVTTELD SWIDKFCLDA DVFVLVANSE STLMQTEKHF FHKVSERLSR PNIFILNNRW DASASEPEYM EEVRRQHMER CTSFLVDELG VVDRSQAGDR IFFVSAKEVL NARIQKAQGM PEGGGALAEG FQVRMFEFQN FERRFEECIS QSA (2-353 aa encoded by BC017061)
Target Information
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CPRP 1; HRP1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; MARF; GTP-binding transmembrane protein; MARF; mitochondrial GTP-binding transmembrane protein; MFN 2; mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin-2-like; Mitofusin2; related to proliferation of VSMCs; transmembrane GTPase MFN2; unnamed protein product
Gene Aliases: CMT2A; CMT2A2; CMT2A2A; CMT2A2B; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; MARF; MSL
UniProt ID: (Human) O95140, (Mouse) Q80U63
Entrez Gene ID: (Human) 9927, (Rat) 64476, (Mouse) 170731
blastocyst formation
mitochondrion organization
mitochondrial membrane organization
spermatogenesis
mitochondrial fusion
negative regulation of cell proliferation
gonad development
male gonad development
aerobic respiration
response to manganese ion
positive regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
positive regulation of hydrogen peroxide biosynthetic process
positive regulation of mitochondrial membrane potential
response to muscle activity
response to nutrient levels
response to testosterone
protein localization to pre-autophagosomal structure
negative regulation of cell cycle
negative regulation of cell size
positive regulation of glucose import
negative regulation of Ras protein signal transduction
positive regulation of insulin receptor signaling pathway
response to cadmium ion
intracellular distribution of mitochondria
camera-type eye morphogenesis
negative regulation of smooth muscle cell proliferation
response to axon injury
mitochondrial calcium ion homeostasis
response to calcium ion
response to electrical stimulus
mitochondrion localization
negative regulation of glial cell proliferation
negative regulation of sarcomere organization
positive regulation of dendritic spine morphogenesis
parkin-mediated mitophagy in response to mitochondrial depolarization
response to fatty acid
cellular response to manganese ion
cellular response to glucose stimulus
cellular response to testosterone stimulus
cellular response to low-density lipoprotein particle stimulus
cellular response to hypoxia
cellular response to ionizing radiation
cellular response to dexamethasone stimulus
cellular response to mercaptoethanol
negative regulation of release of cytochrome c from mitochondria
negative regulation of mitochondrial fission
positive regulation of cold-induced thermogenesis
positive regulation of cellular respiration
negative regulation of reactive oxygen species biosynthetic process
positive regulation of reactive oxygen species biosynthetic process
response to L-arginine
negative regulation of vascular smooth muscle cell proliferation
positive regulation of vascular smooth muscle cell proliferation
cellular response to L-glutamate
response to D-galactose
response to flavonoid
positive regulation of vascular associated smooth muscle cell apoptotic process
response to hypobaric hypoxia
positive regulation of ovarian follicle development
positive regulation of estradiol secretion
positive regulation of progesterone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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