Proteintech

MFN2 Polyclonal Antibody

Product Image Gallery

MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human heart tissue slide using 12186-1-AP ( MFN2 Antibody) at dilution of 1:200 (under 10x lens).

MFN2 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 12186-1-AP (MFN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

MFN2 Antibody in Immunoprecipitation (IP) — IP result of anti-MFN2 (IP:12186-1-AP, 4 ug; Detection:12186-1-AP 1:300) with mouse kidney tissue lysate 4000 ug.

Product Details

Applications

Tested Dilution

Publications

Immunofluorescence (IF)

Assay-dependent

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Western Blot (WB)

1:500-1:1000

View 23 publications 23 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MFN2 Fusion Protein Ag2845

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2

Gene Aliases: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2

UniProt ID: (Human) O95140, (Mouse) Q80U63

Entrez Gene ID: (Human) 9927, (Mouse) 170731, (Rat) 64476

Molecular Function: hydrolase nucleotide phosphatase phosphatase