Search

  • 訂單查詢
  • 快速訂購

Proteintech

MFN2 Polyclonal Antibody

View all (41) MFN2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

Product Details

28341-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MFN2 Fusion Protein Ag28128

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

467 µg/mL

Amount

70.05 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: CPRP 1; HRP1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; MARF; GTP-binding transmembrane protein; MARF; mitochondrial GTP-binding transmembrane protein; MFN 2; mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; mitofusin-2-like; Mitofusin2; related to proliferation of VSMCs; transmembrane GTPase MFN2; unnamed protein product

View more View less

Gene Aliases: CMT2A; CMT2A2; CMT2A2A; CMT2A2B; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; MARF; MSL

View more View less

UniProt ID: (Human) O95140, (Mouse) Q80U63

View more View less

Entrez Gene ID: (Human) 9927, (Rat) 64476, (Mouse) 170731

View more View less

Function(s)
GTPase activity protein binding GTP binding ubiquitin protein ligase binding small GTPase binding identical protein binding proteoglycan binding GTPase binding
Process(es)
blastocyst formation mitochondrion organization mitochondrial membrane organization spermatogenesis mitochondrial fusion negative regulation of cell proliferation gonad development male gonad development aerobic respiration response to manganese ion positive regulation of gene expression negative regulation of cardiac muscle cell apoptotic process positive regulation of hydrogen peroxide biosynthetic process positive regulation of mitochondrial membrane potential response to muscle activity response to nutrient levels response to testosterone protein localization to pre-autophagosomal structure negative regulation of cell cycle negative regulation of cell size positive regulation of glucose import negative regulation of Ras protein signal transduction positive regulation of insulin receptor signaling pathway response to cadmium ion intracellular distribution of mitochondria camera-type eye morphogenesis negative regulation of smooth muscle cell proliferation response to axon injury mitochondrial calcium ion homeostasis response to calcium ion response to electrical stimulus mitochondrion localization negative regulation of glial cell proliferation negative regulation of sarcomere organization positive regulation of dendritic spine morphogenesis parkin-mediated mitophagy in response to mitochondrial depolarization response to fatty acid cellular response to manganese ion cellular response to glucose stimulus cellular response to testosterone stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to mercaptoethanol negative regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission positive regulation of cold-induced thermogenesis positive regulation of cellular respiration negative regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process response to L-arginine negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular smooth muscle cell proliferation cellular response to L-glutamate response to D-galactose response to flavonoid positive regulation of vascular associated smooth muscle cell apoptotic process response to hypobaric hypoxia positive regulation of ovarian follicle development positive regulation of estradiol secretion positive regulation of progesterone secretion
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support