This gene is a member of the fringe gene family which also includes radical and lunatic fringe genes. They all encode evolutionarily conserved secreted proteins that act in the Notch receptor pathway to demarcate boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling.
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Protein Aliases: Beta-1,3-N-acetylglucosaminyltransferase manic fringe; EC 184.108.40.206; manic fringe homolog; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Gene Aliases: AW546563; MFNG
Molecular Function: glycosyltransferase