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Product Details
PA5-21050
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1-2 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
A 15 amino acid peptide near the center of human MFSD2B. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C |
RRID |
AB_11155222 |
Product Specific Information
A suggested positive control is rat lung tissue lysate.
PA5-21050 can be used with blocking peptide PEP-1164.
Target Information
Multidrug transporters, such as MFSD2B, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2B is closely related to MFSD2A, which is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting, playing a major role in the induction of MFSD2A expression during adaptive thermogenesis. Unlike MFSD2A, MFSD2B is expressed in few tissues and at relatively low levels, and is not induced during fasting, suggesting that MFSD2B may play other roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMfsd2b; major facilitator superfamily domain containing 2B; Major facilitator superfamily domain-containing protein 2B; Sphingosine-1-phosphate transporter MFSD2B
Gene Aliases: MFSD2B; RGD1561716
UniProt ID: (Human) A6NFX1
Entrez Gene ID: (Human) 388931, (Rat) 500624
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