Immunogen sequence: MVDLTQVMDD EVFMAFASYA TIILSKMMLM STATAFYRLT RKVFANPEDC VAFGKGENAK KYLRTDDRVE RVRRAHLNDL ENIIPFLGIG LLYSLSGPDP; Positive Samples: Mouse lung; Cellular Location: Endoplasmic reticulum membrane, Microsome, Mitochondrion outer membrane, Multi-pass membrane protein, Peripheral membrane protein
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress.
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Protein Aliases: glutathione S-transferase 12; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I
Gene Aliases: 1500002K10Rik; Gst; GST12; MGST; MGST-I; MGST1