Immunogen sequence: MPWRGRRFRLC RRKMAVLSK
Highest antigen sequence identity to the following orthologs - mouse 40%, rat 40%.
The MAPEG family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.
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Protein Aliases: Glutathione peroxidase MGST3; LTC4 synthase MGST3; Microsomal glutathione S-transferase 3; Microsomal glutathione S-transferase III; Microsomal GST-3; Microsomal GST-III
Gene Aliases: GST-III; MGST3
UniProt ID: (Human) O14880
Entrez Gene ID: (Human) 4259
Molecular Function: transferase