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Invitrogen
CD13 Monoclonal Antibody (TUK 1), APC
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FIGURE: 1 / 1
CD13 Antibody (MHCD1305) in Flow
Antigen Specificity: According to the literature this antibody recognizes the CD13 antigen. Also known as amino-peptidase N, this molecule functions as a zinc metalloproteinase in the metabolism of regulatory proteins. CD13 is primarily expressed on granulocytes, GM-progenitor cells, mast cells and monocytes. The molecule is not expressed on erythrocytes, lymphocytes or platelets.
Product Details
MHCD1305
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
TUK 1
Immunogen
Human CD13
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with 4mg/mL BSA, sucrose
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.
Target Information
CD13, also known as ANPEP, is a 150-170 kDa type II transmembrane zinc-binding ectopeptidase expressed on a wide variety of cell types and tissues. It is prominently found on monocytes and granulocytes in the blood, but not on lymphocytes. Additionally, CD13 is expressed on endothelial cells, epithelial cells, fibroblasts, kidney proximal tubules, intestine, placenta, and myeloid leukemia cells. As a metalloprotease, CD13 preferentially catalyzes the removal of neutral amino acids from small peptides, thereby activating or inactivating bioactive peptides. It plays a crucial role in various biological processes, including the degradation of enkephalins and endorphins, terminal degradation of peptides, amino acid scavenging, antigen processing, and the adhesion and migration of cells. CD13 is also involved in extracellular matrix degradation, signal transduction, inflammatory responses, regulation of intercellular contact, cell motility, and vascularization. In the context of disease, CD13 is associated with the protection of leukemic cells against apoptosis and is linked to a poor prognosis in carcinomas. Furthermore, CD13 functions as an aminopeptidase enzyme and serves as an alpha receptor for coronavirus.
Analyte Specific Reagent
How to use the Panel Builder
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Bioinformatics
Protein Aliases: alanyl (membrane) aminopeptidase; Alanyl aminopeptidase; Aminopeptidase M; Aminopeptidase N; aminopeptidase N precursor (EC 3.4.11.2); AP-M; AP-N; CD13; gp150; h AP-N; membrane alanyl aminopeptidase; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; unnamed protein product
Gene Aliases: ANPEP; AP-M; AP-N; APN; CD13; GP150; hAPN; LAP1; P150; PEPN
UniProt ID: (Human) P15144
Entrez Gene ID: (Human) 290
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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