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Invitrogen
Fetal Hemoglobin Monoclonal Antibody (HBF-1), PE
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Product Details
MHFH04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
HBF-1
Immunogen
Human Fetal Hemoglobin (HbF)
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
PBS with <10% sucrose, BSA
Contains
0.1% sodium azide
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.
This antibody specifically recognizes fetal hemoglobin found in fetal erythrocytes.
Target Information
Hemorrhage of cells from an Rh+ fetus into the circulation of an Rh- mother may result in the formation of Rh-reactive antibodies in the mother. Rh hemolytic anemia in a subsequent Rh+ fetus may result from placental transfer of antibodies formed in the mother to the fetus. Although the volume of fetal erythrocytes found in the maternal circulation during pregnancy and immediately post-partum is reported to be small and of uncertain clinical significance in many cases, substantial hemorrhage may result from a number of causes including fetal or maternal trauma and placental defects. Erythrocytes containing fetal hemoglobin may be found in individuals of any age, but with lower amounts of fetal hemoglobin compared to fetal red cells. These cells have been termed F cells. High levels of F cells may also exist in adults with a heterogeneous group of genetic disorders of uncertain etiology, referred to as Hereditary Persistence of Fetal Hemoglobin. Other clinical conditions causing significant levels of anemia may also result in elevated levels of F cells. Several clinical conditions have been described with increased levels of F cells. These conditions include hereditary anemic diseases such as sickle cell anemia and thalassemia major.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-gamma globin; alpha-1 globin; fetal hemoglobin F subunit gamma 1; gamma A hemoglobin; gamma globin; Gamma-1-globin; Hb F Agamma; hemoglobin alpha 1; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain; Hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of; unnamed protein product
Gene Aliases: HBG-T2; HBG1; HBGA; HBGR; HSGGL1; PRO2979
UniProt ID: (Human) P69891
Entrez Gene ID: (Human) 3047
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