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Invitrogen
MIA3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106940
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MIA3(Accession Q5JRA6), corresponding to amino acid residues P1844-S1894.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MIA3.
Target Information
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C219-reactive peptide; KIAA0268; melanoma inhibitory activity 3; melanoma inhibitory activity family, member 3; melanoma inhibitory activity protein 3; MIA family member 3, ER export factor; RP11-378J18.4; secreted protein; unnamed protein product
Gene Aliases: 9130229H14Rik; A930039G15Rik; B230399H06Rik; D320; Gm1525; ODCD2; TANGO; TANGO1; UNQ6077
UniProt ID: (Human) Q5JRA6, (Mouse) Q8BI84
Entrez Gene ID: (Human) 375056, (Mouse) 338366, (Rat) 683007
cell migration involved in sprouting angiogenesis
positive regulation of leukocyte migration
exocytosis
ER to Golgi vesicle-mediated transport
endoplasmic reticulum organization
negative regulation of cell adhesion
protein secretion
protein transport
negative regulation of cell migration
cargo loading into vesicle
wound healing
lipoprotein transport
system development
protein localization to endoplasmic reticulum exit site
cargo loading into COPII-coated vesicle
cellular response to oxidised low-density lipoprotein particle stimulus
negative regulation of leukocyte cell-cell adhesion
negative regulation of lymphocyte migration
chondrocyte development
collagen fibril organization
positive regulation of bone mineralization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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