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Product Details
PA5-63209
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MIA3. Recombinant protein control fragment (Product #RP-99801).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2643948
Product Specific Information
Immunogen sequence: DSKQGKPQSA TDYSDPDNVD DGLFIVDIPK TNNDKEVNAE HHIKGKGRGV QESKRGLVQD ETELEDENQE GMTVHSSVHS NNLNSMPA
Highest antigen sequence identity to the following orthologs: Mouse - 25%, Rat - 26%.
Target Information
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C219-reactive peptide; D320; melanoma inhibitory activity family member 3; melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; RP11-378J18.4; TANGO1; transport and Golgi organization protein 1; Transport and Golgi organization protein 1 homolog
Gene Aliases: ARNT; D320; KIAA0268; MIA3; TANGO; TANGO1; UNQ6077; UNQ6077/PRO20088
UniProt ID: (Human) Q5JRA6
Entrez Gene ID: (Human) 375056
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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