Search
Proteintech
MIB1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
11893-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MIB1 Fusion Protein Ag2507 (707-1006 aa encoded by BC022403)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LRHHTLSQL RQLQDMQDVG KVDAAWEPSK NTLIMGLGTQ GAEKKSAASI ACFLAANGAD LSIRNKKGQS PLDLCPDPNL CKALAKCHKE KVSGQVGSRS PSMISNDSET LEECMVCSDM KRDTLFGPCG HIATCSLCSP RVKKCLICKE QVQSRTKIEE CVVCSDKKAA VLFQPCGHMC ACENCANLMK KCVQCRAVVE RRVPFIMCCG GKSSEDATDD ISSGNIPVLQ KDKDNTNVNA DVQKLQQQLQ DIKEQTMCPV CLDRLKNMIF LCGHGTCQLC GDRMSECPIC RKAIERRILL Y (707-1006 aa encoded by BC022403)
Target Information
MIB is an E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. This protein positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. MIB probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DAPK-interacting protein 1; DIP-1; E3 ubiquitin-protein ligase MIB1; Mind bomb homolog 1; mindbomb E3 ubiquitin protein ligase 1; RING-type E3 ubiquitin transferase MIB1; ubiquitin ligase mind bomb; unnamed protein product; Zinc finger ZZ type with ankyrin repeat domain protein 2
Gene Aliases: DIP-1; DIP1; KIAA1323; LVNC7; MIB; MIB1; ZZANK2; ZZZ6
UniProt ID: (Human) Q86YT6
Entrez Gene ID: (Human) 57534
blood vessel development
in utero embryonic development
somitogenesis
neural tube formation
heart looping
ubiquitin-dependent protein catabolic process
endocytosis
Notch signaling pathway
heart development
protein ubiquitination
central nervous system neuron differentiation
negative regulation of neuron differentiation
positive regulation of endocytosis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support