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Invitrogen
MICA Polyclonal Antibody
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FIGURE: 1 / 3
MICA Antibody (PA5-80811) in IHC (P)
Immunohistochemical staining of human MICA in human breast-carcinoma with MICA Polyclonal Antibody (Product # PA5-80811, 1:1,000, formalin-fixed paraffin embedded sections). Left panel: tissue incubated with primary antibody. Right panel: tissue incubated with mixture of primary antibody and antigen (recombinant protein).
Product Details
PA5-80811
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human MICA protein (Met1-Gln308)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human MICA.
Target Information
Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cell stress-regulated membrane protein; DAMA-345G11.2; HLA class I antigen; major histocompatibility complex class I chain-related protein A; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related chain A; MHC class I related sequence A; MIC-A; stress inducible class I homolog; unnamed protein product
Gene Aliases: MIC-A; MICA; PERB11.1
UniProt ID: (Human) Q95IY7
Entrez Gene ID: (Human) 100507436
T cell mediated cytotoxicity
adaptive immune response
immune system process
immune response to tumor cell
immune response
cellular response to DNA damage stimulus
signal transduction
response to heat
negative regulation of defense response
killing of cells of other organism
negative regulation of natural killer cell activation
natural killer cell mediated cytotoxicity
defense response to bacterium
negative regulation of natural killer cell mediated cytotoxicity
gamma-delta T cell activation
regulation of immune response
defense response to virus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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