This antibody can recognize both MICAL2 and MICAL2-PV. This antibody recognizes various isoforms of MICAL2 around 90-95 kDa or 109-112 kDa.
MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: [F-actin]-monooxygenase MICAL2; flavoprotein oxidoreductase MICAL2; KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; microtubule associated monoxygenase, calponin and LIM domain containing 2; mMical2; Molecule interacting with CasL protein 2; Protein MICAL 2; protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2
Gene Aliases: 5330438E18Rik; 9530064J02; KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; mKIAA0750; RGD1311773