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Invitrogen
MICAL2 Polyclonal Antibody
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FIGURE: 1 / 3
MICAL2 Antibody (PA5-100613) in IHC (P)
Immunohistochemistry analysis of MICAL2 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MICAL2 polyclonal antibody (Product # PA5-100613) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-100613
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MICAL2(Accession O94851), corresponding to amino acid residues K866-S916.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MICAL2.
Target Information
MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [F-actin]-methionine sulfoxide oxidase MICAL2; ebitein-1; ebitein1; ERK2-binding testicular protein 1; F-actin-monooxygenase MICAL2; flavoprotein oxidoreductase MICAL2; MICAL C-terminal like; MICAL C-terminal-like protein; MICAL C-terminal-like protein-like; mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; mMical2; molecule interacting with CasL protein 2; protein MICAL-2; protein-methionine sulfoxide oxidase MICAL2; unnamed protein product
Gene Aliases: 4921517J23Rik; 5330438E18Rik; 9530064J02; Ebitein1; MICAL-2; mical-cL; MICAL2PV1; MICAL2PV2; MICALCL; mKIAA0750; RGD1311773; RSB-11-77
UniProt ID: (Human) O94851, (Rat) D4A1F2, (Mouse) Q8BML1
Entrez Gene ID: (Human) 9645, (Rat) 365352, (Mouse) 320878
actin binding
protein binding
NAD(P)H oxidase activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
mitogen-activated protein kinase binding
FAD binding
F-actin monooxygenase activity
monooxygenase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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