Immunogen sequence: LKGKLTIKNF LEFQRKLQHD VLKLEFERHD PVDGRITERQ FGGMLLAYSG VQSKKLTAMQ RQLKKHFKEG KGLTFQEVEN FFTFL
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
MICU1 is a key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. It may act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. MICU1 induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
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Protein Aliases: ara CALC; Atopy-related autoantigen CALC; Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1; DKFZp564C246; FLJ12684; Hom s 4
Gene Aliases: CALC; CBARA1; EFHA3; MICU1; MPXPS
UniProt ID: (Human) Q9BPX6
Entrez Gene ID: (Human) 10367