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Product Details
PA5-117727
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant Human Probable E3 ubiquitin-protein ligase MID2 protein (506-735aa) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.35 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C or -80°C if preferred |
RRID |
AB_2902356 |
Product Specific Information
This antibody has been tested in direct-ELISA
Target Information
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ37715; FLJ41813; midin 2; Midin-2; Midline defect 2; Midline-2; Probable E3 ubiquitin-protein ligase MID2; RING finger protein 60; RING-type E3 ubiquitin transferase MID2; RP6-191P20.2; tripartite motif protein 1; Tripartite motif-containing protein 1
Gene Aliases: FXY2; MID2; MRX101; RNF60; TRIM1
UniProt ID: (Human) Q9UJV3, (Mouse) Q9QUS6
Entrez Gene ID: (Human) 11043, (Mouse) 23947
Molecular Function:
ubiquitin-protein ligase
positive regulation of autophagy
protein ubiquitination
negative regulation of viral transcription
protein localization to microtubule
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
negative regulation of viral entry into host cell
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
negative regulation of viral release from host cell
microtubule binding
zinc ion binding
ligase activity
protein homodimerization activity
protein heterodimerization activity
phosphoprotein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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