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Product Details
11452-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:4,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
MIER1 Fusion Protein Ag2010 (49-224 aa encoded by BC017423) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.44 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: SADMLVHDF DDERTLEEEE MMEGETNFSS EIEDLAREGD MPIHELLSLY GYGSTVRLPE EDEEEEEEEE EGEDDEDADN DDNSGCSGEN KEENIKDSSG QEDETQSSND DPSQSVASQD AQEIIRPRRC KYFDTNSEVE EESEEDEDYI PSEDWKKEIM VGSMFQAEIP VGICRY (49-224 aa encoded by BC017423)
Target Information
The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Early response 1; hMI-ER1; mesoderm induction early response 1 homolog; mesoderm induction early response 1, transcriptional regulator; Mesoderm induction early response protein 1; RP5-944N15.1
Gene Aliases: 4933425I22Rik; 5830411K19Rik; ER1; KIAA1610; MI-ER1; MIER1; RGD1562337
UniProt ID: (Human) Q8N108, (Mouse) Q5UAK0
Entrez Gene ID: (Human) 57708, (Mouse) 71148, (Rat) 313418
Molecular Function:
homeodomain transcription factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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