Human MIF shares 89% and 90% amino acid (aa) sequence identity with mouse and rat MIF respectively.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 ug/mL.
MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). Recently, MIF was rediscovered as a pituitary hormone that act as the counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995). MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998). MIF plays a critical role in the host control of inflammation and immunity.
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Protein Aliases: 184.108.40.206; 220.127.116.11; GIF; GLIF, MMIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; Macrophage migration inhibitory factor; MIF; Phenylpyruvate tautomerase
Gene Aliases: GIF; GLIF; MIF; MMIF
UniProt ID: (Human) P14174
Entrez Gene ID: (Human) 4282