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Proteintech
MINA Polyclonal Antibody
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Product Details
12214-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MINA Fusion Protein Ag2838 (160-465 aa encoded by BC014928)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLVGSNVYI TPAGSQGLPP HYDDVEVFIL QLEGEKHWRL YHPTVPLARE YSVEAEERIG RPVHEFMLKP GDLLYFPRGT IHQADTPAGL AHSTHVTIST YQNNSWGDFL LDTISGLVFD TAKEDVELRT GIPRQLLLQV ESTTVATRRL SGFLRTLADR LEGTKELLSS DMKKDFIMHR LPPYSAGDGA ELSTPGGKLP RLDSVVRLQF KDHIVLTVLP DQDQSDETQE KMVYIYHSLK NSRETHMMGN EEETEFHGLR FPLSHLDALK QIWNSPAISV KDLKLTTDEE KESLVLSLWT ECLIQVV (160-465 aa encoded by BC014928 )
Target Information
MINA is nuclear localized, myc-inducible protein that is thought to play a role in mammalian cell proliferation. Treatment of cancer cells lines such as the colon cancer cell line SW680 with siRNA against MINA inhibits cell growth, demonstrating that MINA may be a potential therapeutic target. MINA regulates several genes related to cell adhesion and metabolism that have also been shown to be regulated by c-Myc, but also regulates other genes whose expression are not modulated by c-Myc such as EGFR, IL-6 and HGF. MINA has also been found to act as a repressor to IL-4 expression in T cells, indicating that it may also play a role in T cell differentiation and genetic variation in T helper type 2 bias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 60S ribosomal protein L27a histidine hydroxylase; Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; DKFZp762O1912; FLJ14393; Histone lysine demethylase MINA; MDIG2; cell cycle regulatory protein; mina; mina {ECO:0000312|RGD:708521}; Mina-53; mineral dust induced gene; mineral dust induced gene protein; mineral dust-induced gene; Mineral dust-induced gene protein; mineral dust-induced protein; mina53; nucleolar protein; NO52; ribosomal oxygenase 2; RIOX2; JMJD10; MYC induced nuclear antigen; MYC-induced nuclear antigen; MYC-induced nuclear antigen 53; myc-induced nuclear antigen, 53 kDa; Nucleolar protein 52; Protein mina53; Ribosomal oxygenase 2; Ribosomal oxygenase MINA; ROX; unnamed protein product
Gene Aliases: 1810047J07Rik; 2410057H13Rik; 3830408E23Rik; AI449204; JMJD10; MDIG; MINA; MINA53; NO52; RIOX2; ROX
UniProt ID: (Mouse) Q8CD15, (Rat) Q8CFC1, (Human) Q8IUF8
Entrez Gene ID: (Mouse) 67014, (Rat) 266670, (Human) 84864
sulfonate dioxygenase activity
transcriptional repressor activity, RNA polymerase II transcription factor binding
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
metal ion binding
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
transcription corepressor activity
protein binding
histone demethylase activity
histone demethylase activity (H3-K4 specific)
peptidyl-histidine dioxygenase activity
identical protein binding
histone demethylase activity (H3-K36 specific)
chromatin remodeling
ribosome biogenesis
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell proliferation
regulation of cell proliferation
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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