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Immunogen sequence: MGDPAPARS LDDIDLSALR DPAGIFELVE VVGNGTYGQV YKGRHVKTGQ LAAIKVMDVT EDEEEEIKQE INMLKKYSHH RNIATYYGAF IKKSPPGNDD QLWLVMEFCG AGSVTDLVKN TKGNALKEDC IAYICREILR GLAHLHAHKV IHRDIKGQNV LLTENAEVKL VDFGVSAQLD RTVGRRNTFI GTPYWMAPEV IACDENPDAT YDYRSDIWSL GITAIEMAEG APPLCDMHPM RALFLIPRNP PPRLKSKKWS KKFIDFIDTC LIKTYLSRPP TEQLLKFPFI RDQPTERQVR IQLKD (1-304 aa encoded by BC034673)
MINK1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.
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Protein Aliases: FLJ18426; FLJ38123; FLJ94103; GCK family kinase MINK; hMINK; hMINKbeta; ISK; JLNS; JLNS2; LQT2/5; LQT5; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MGC33114; Mink 1; Mink 2; mink1; Misshapen-like kinase 1; Misshapen/NIK-related kinase; Misshapen/NIKs-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6; Yeast Sps1/Ste20-related kinase 2
Gene Aliases: B55; MAP4K6; MEKKK 6; MINK; MINK1; YSK2; ZC3
UniProt ID: (Human) Q8N4C8, (Mouse) Q9JM52
Entrez Gene ID: (Human) 50488, (Mouse) 50932, (Rat) 303259
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