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Product Details
PA5-28250
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 884 and 1291 of Human MAP4K6
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2545726
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7.^M
^M
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (87%), Xenopus laevis (89%), Bovine (99%).^M
^M
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
MINK1 is a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ18426; FLJ38123; FLJ94103; GCK family kinase MINK; hMINK; hMINKbeta; ISK; JLNS; JLNS2; LQT2/5; LQT5; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; MGC33114; Mink 1; Mink 2; Misshapen-like kinase 1; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
Gene Aliases: B55; MAP4K6; MINK; MINK1; YSK2; ZC3
UniProt ID: (Human) Q8N4C8
Entrez Gene ID: (Human) 50488
regulation of cell-matrix adhesion
protein phosphorylation
response to stress
JNK cascade
chemical synaptic transmission
multicellular organism development
regulation of cell-cell adhesion
microvillus assembly
regulation of cell migration
actin cytoskeleton reorganization
intracellular signal transduction
positive regulation of JNK cascade
protein autophosphorylation
dendrite morphogenesis
regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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