Invitrogen

MIP-3 beta Polyclonal Antibody

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MIP-3 beta Polyclonal Antibody

Product Details

PA5-84767

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CCL19. Recombinant protein control fragment (Product #RP-107597).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2791917

Product Specific Information

Immunogen sequence: LLIKDGCRVP AVVFTTLRGR QLCAPPDQPW VERIIQRLQR TSAKMKRRSS

Highest antigen sequence indentity to the following orthologs: Rat - 76%, Mouse - 76%.

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: beta chemokine exodus-3; Beta-chemokine exodus-3; C-C motif chemokine; C-C motif chemokine 19; CC chemokine ligand 19; chemokine (C-C motif) ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; M-MIP-3-beta; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP-3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19

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Gene Aliases: CCL19; CKb11; ELC; MIP-3b; MIP3B; SCYA19

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UniProt ID: (Human) Q99731

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Entrez Gene ID: (Human) 6363

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Function(s)
chemokine activity CCR7 chemokine receptor binding CCR10 chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cytokine intercellular signal molecule
Process(es)
establishment of T cell polarity immunological synapse formation dendritic cell chemotaxis myeloid dendritic cell chemotaxis monocyte chemotaxis positive regulation of dendritic cell antigen processing and presentation cellular calcium ion homeostasis inflammatory response immune response cell communication G-protein coupled receptor signaling pathway activation of JUN kinase activity response to virus positive regulation of glycoprotein biosynthetic process T cell costimulation positive regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to prostaglandin E positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of T-helper 1 cell differentiation positive regulation of endocytosis positive regulation of protein kinase activity positive regulation of JNK cascade lymphocyte chemotaxis positive regulation of receptor-mediated endocytosis cell maturation positive regulation of interleukin-1 beta secretion positive regulation of chemotaxis release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling regulation of cell projection assembly chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor response to nitric oxide interleukin-12 secretion positive regulation of neutrophil chemotaxis mature conventional dendritic cell differentiation cellular response to virus negative regulation of leukocyte apoptotic process positive regulation of cell motility positive regulation of dendritic cell dendrite assembly
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