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Proteintech
MITF Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13092-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MITF Fusion Protein Ag3679 (1-91 aa encoded by BC012503)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLEMLEYNH YQVQTHLENP TKYHIQQAQR QQVKQYLSTT LANKHANQVL SLPCPNQPGD HVMPPVPGSS APNSPMAMLT LNSNCEKEFM KQ (1-91 aa encoded by BC012503)
Target Information
Mi is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52 kDa and 56 kDa, while the longer Mi form runs as a cluster of bands at 60-70 kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: b-HLH-ZIP transcription factor; black eyed white; class E basic helix-loop-helix protein 32; melanogenesis associated transcription factor; microphtalmia-associated transcription factor; microphthalmia; Mitf-B; Mitf-C; unnamed protein product
Gene Aliases: BCC2; Bhlhe32; bw; CMM8; COMMAD; Gsfbcc2; MI; MITF-A; vit; Vitiligo; Wh; WS2; WS2A
UniProt ID: (Human) O75030, (Rat) O88368, (Mouse) Q08874
Entrez Gene ID: (Human) 4286, (Rat) 25094, (Mouse) 17342
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
E-box binding
sequence-specific DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
melanocyte differentiation
negative regulation of cell migration
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
developmental pigmentation
protein-containing complex assembly
positive regulation of DNA-templated transcription, initiation
regulation of RNA biosynthetic process
transcription, DNA-templated
regulation of gene expression
Wnt signaling pathway
cell differentiation
osteoclast differentiation
cellular response to zinc ion starvation
regulation of cell proliferation
camera-type eye development
negative regulation of apoptotic process
pigmentation
cell fate commitment
response to ethanol
regulation of osteoclast differentiation
positive regulation of cell size
bone remodeling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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