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Bethyl Laboratories
MKL2 Polyclonal Antibody
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FIGURE: 1 / 1
MKL2 Antibody (A302-767A) in IP
Detection of human MKL2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-MKL2 antibody (Product # A302-767A) used for IP at 3 µg/mg lysate. MKL2 was also immunoprecipitated by rabbit anti-MKL2 antibody A302-768A, which recognizes a downstream epitope. For blotting immunoprecipitated MKL2, A302-768A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
Product Details
A302-767A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 900 and 950 of human Megakaryoblastic Leukemia 2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CTA-276F8.1; Megakaryoblastic leukemia 2; MKL and myocardin family member 2; MKL/myocardin like 2; MKL/myocardin-like protein 2; MKL1/myocardin like 2; MRTF-B; Myocardin-related transcription factor B; transcriptional co-activator; unnamed protein product
Gene Aliases: KIAA1243; MKL2; MRTF-B; MRTFB; NPD001
UniProt ID: (Human) Q9ULH7
Entrez Gene ID: (Human) 57496
muscle organ development
cell differentiation
positive regulation of striated muscle tissue development
positive regulation of transcription from RNA polymerase II promoter
smooth muscle cell differentiation
regulation of modification of postsynaptic structure
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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