Immunogen sequence: IIGVGKEDYP HTQGDFSFDE DSSDALSPDQ PASQESQGSA ASPSEPKVSE SPSPVTTNTP AQFASVSPTV PEFLKTPPTA DQPPPRPAAP VLPTNTVSSA KPGPALVKQS HPKNPNDKHR SKKCKDPKPR V; Positive Samples: LO2, Jurkat, Mouse pancreas; Cellular Location: Nucleus
Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factors A and B (MRTF-A and MRTF-B) interact with SRF and act as stimulators for its transcriptional activity. MRTF-B is crucial for skeletal myogenic differentiation.
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Protein Aliases: CTA-276F8.1; gene trap insertion site 4-1; Megakaryoblastic leukemia 2; MKL/myocardin like 2; MKL/myocardin-like 2; MKL/myocardin-like protein 2; MRTF-B; Myocardin-related transcription factor B
Gene Aliases: ENSMUSG00000075401; Gt4-1; KIAA1243; mKIAA1243; MKL2; MRTF-B; MRTFB; NPD001
Molecular Function: transcription factor