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Invitrogen
MKP2 Polyclonal Antibody
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FIGURE: 1 / 1
MKP2 Antibody (PA5-96197) in WB
Western blot analysis of MKP2 in extracts of various cell lines. Samples were incubated with MKP2 Polyclonal antibody (Product # PA5-96197) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96197
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human DUSP4 (NP_0013851)
Conjugate
Form
Liquid
Concentration
1.72 mg/mL
Amount
172 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MVTMEELREM DCSVLKRLMN RDENGGGAGG SGSHGTLGLP SGGKCLLLDC RPFLAHSAGY ILGSVNVRCN TIVRRRAKGS VSLEQILPAE EEVRARLRSG LYSAVIVYDE RSPRAESLRE DSTVSLVVQA LRRNAERTDI CLLKGGYERF SSEYPEFCSK TKALAAIP; Positive Samples: COS-7, HeLa, A375; Cellular Location: Nucleus
Target Information
DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP-4; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP II; MKPII; serine/threonine specific protein phosphatase; unnamed protein product; VH1 homologous phosphatase 2
Gene Aliases: DUSP4; HVH2; MKP-2; MKP2; TYP; VH2
UniProt ID: (Human) Q13115
Entrez Gene ID: (Human) 1846
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
protein tyrosine phosphatase activity
protein binding
protein tyrosine/threonine phosphatase activity
hydrolase activity
phosphatase activity
MAP kinase tyrosine/serine/threonine phosphatase activity
MAP kinase phosphatase activity
MAP kinase threonine phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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