Invitrogen

MKS1 Polyclonal Antibody

Product Image Gallery

MKS1 Antibody in Immunohistochemistry (IHC) — Immunohistochemical staining of MKS1 in human cerebral cortex, colon, fallopian tube and kidney using MKS1 Polyclonal Antibody (Product # PA5-54392) (A) shows similar protein distribution across tissues to an independent MKS1 Polyclonal Antibody (B).

MKS1 Antibody in Western Blot (WB) — Western blot analysis of MKS1 in Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells); Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells). Samples were probed using a MKS1 Polyclonal Antibody (Product # PA5-54392).

Product Details

Tested Applications

Dilution

Immunohistochemistry (IHC)

1:50-1:200

Western Blot (WB)

0.4 µg/mL

Product Specifications

Species Reactivity

Human, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human MKS1

Conjugate

Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2643995

Product Specific Information

Immunogen sequence: EVPSFLVERM ANVRRRRQDR RGMEGGILKS RIVTWEPSEE FVRNNHVINT PLQTMHIMAD LGPYKKLGYK KYEHVLCTLK VDSNGVITVK PDFTGLKGPY RI

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.

Target Information

The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BBS13; FABB proteome-like protein; Meckel syndrome type 1 protein; Meckel syndrome type 1 protein homolog; MES; MKS; POC12; POC12 centriolar protein homolog

Gene Aliases: BBS13; MES; MKS; MKS1; POC12

UniProt ID: (Human) Q9NXB0, (Rat) Q499Q5

Entrez Gene ID: (Human) 54903, (Rat) 287612

Molecular Function: extracellular matrix protein