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Product Details
PA5-54392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MKS1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2643995
Product Specific Information
Immunogen sequence: EVPSFLVERM ANVRRRRQDR RGMEGGILKS RIVTWEPSEE FVRNNHVINT PLQTMHIMAD LGPYKKLGYK KYEHVLCTLK VDSNGVITVK PDFTGLKGPY RI
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 85%.
Target Information
The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Meckel syndrome type 1 protein; Meckel syndrome type 1 protein homolog; POC12 centriolar protein homolog; Tectonic-like complex member MKS1
Gene Aliases: BBS13; MES; MKS; MKS1; POC12
UniProt ID: (Human) Q9NXB0, (Rat) Q499Q5
Entrez Gene ID: (Human) 54903, (Rat) 287612
Molecular Function:
structural protein
neural tube closure
determination of left/right symmetry
epithelial structure maintenance
nonmotile primary cilium assembly
cilium assembly
embryonic digit morphogenesis
embryonic skeletal system development
branching morphogenesis of an epithelial tube
inner ear receptor stereocilium organization
cilium morphogenesis
head development
regulation of canonical Wnt signaling pathway
common bile duct development
regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
motile primary cilium assembly
embryonic brain development
regulation of Wnt signaling pathway, planar cell polarity pathway
regulation of smoothened signaling pathway
motile cilium assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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