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Product Details
BS-2992R-A594
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MLK3
Conjugate
Excitation/Emission Max
590/618 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAP3K11 (MLK3) is a serine/threonine kinase that activates both the p38 MAP kinase and c-Jun kinase pathways. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP3K11; MGC17114; mitogen activated protein kinase kinase kinase 11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; Src-homology 3 domain-containing proline-rich kinase
Gene Aliases: 2610017K16Rik; MAP3K11; MEKK11; MLK-3; MLK3; PTK1; RHOE; SPRK
UniProt ID: (Human) Q16584, (Rat) Q66HA1, (Mouse) Q80XI6
Entrez Gene ID: (Human) 4296, (Rat) 309168, (Mouse) 26403
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
protein binding
ATP binding
mitogen-activated protein kinase kinase binding
mitogen-activated protein kinase kinase kinase binding
identical protein binding
protein homodimerization activity
Rac GTPase binding
MAP kinase kinase kinase activity
protein tyrosine kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
activation of MAPK activity
protein phosphorylation
microtubule-based process
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
cell death
cell proliferation
positive regulation of JUN kinase activity
positive regulation of neuron apoptotic process
positive regulation of JNK cascade
protein autophosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of apoptotic process
phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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