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Active Motif
MLL / HRX Polyclonal Antibody
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Product Details
61295
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 2829-2883 of human MLL.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.5, with 30% glycerol
Contains
0.035% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acute lymphocytic 1; ALL-1; CXXC-type zinc finger protein 7; Cysteine methyltransferase KMT2A; e10e5; Histone-lysine N-methyltransferase 2A; histone-lysine N-methyltransferase MLL; HRX; lysine (K)-specific methyltransferase 2A; Lysine N-methyltransferase 2A; mixed lineage leukemia 1; MLL; Myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia 1; Myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax Drosophila; Trithorax-like protein; trx Zinc-finger region homolog; unnamed protein product; Zinc finger protein HRX
Gene Aliases: 6430520K01; ALL-1; ALL1; CXXC7; GAS7; HRX; HTRX; HTRX1; KMT2A; mKIAA4050; MLL; MLL1; MLL1A; TRX1; WDSTS
UniProt ID: (Human) Q03164
Entrez Gene ID: (Human) 4297, (Mouse) 214162
DNA binding
AT DNA binding
chromatin binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity (H3-K4 specific)
identical protein binding
protein homodimerization activity
unmethylated CpG binding
metal ion binding
protein-cysteine methyltransferase activity
histone H3K4 monomethyltransferase activity
histone H3K4 trimethyltransferase activity
core promoter sequence-specific DNA binding
histone-lysine N-methyltransferase activity
transcription regulatory region DNA binding
lysine-acetylated histone binding
histone modifying enzyme
immune system process
chromatin organization
regulation of transcription, DNA-templated
apoptotic process
visual learning
response to light stimulus
post-embryonic development
anterior/posterior pattern specification
regulation of gene expression
positive regulation of gene expression
methylation
circadian regulation of gene expression
embryonic hemopoiesis
exploration behavior
response to potassium ion
protein modification process
regulation of gene expression, epigenetic
T-helper 2 cell differentiation
positive regulation of gene expression, epigenetic
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
fibroblast proliferation
negative regulation of fibroblast proliferation
regulation of short-term neuronal synaptic plasticity
rhythmic process
spleen development
homeostasis of number of cells within a tissue
cognition
membrane depolarization
definitive hemopoiesis
protein-containing complex assembly
cellular response to transforming growth factor beta stimulus
negative regulation of methylation-dependent chromatin silencing
DNA methylation
transcription, DNA-templated
protein complex assembly
negative regulation of cell proliferation
chromatin modification
positive regulation of transporter activity
histone H4-K16 acetylation
histone H3-K4 methylation
regulation of histone H3-K4 methylation
positive regulation of histone H3-K4 methylation
regulation of histone H3-K14 acetylation
histone H3-K4 trimethylation
regulation of histone H3-K9 acetylation
positive regulation of cellular response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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