MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastasis.
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Protein Aliases: matrix metallo protease; matrix metallopeptidase 15 (membrane-inserted); matrix metalloproteinase 15 (membrane-inserted); Matrix metalloproteinase-15; Membrane-type matrix metalloproteinase 2; Membrane-type-2 matrix metalloproteinase; MMP; MMP-15; MMPs; MT-MMP 2; MT2-MMP; SMCP-2
Gene Aliases: MMP-15; MMP15; MT2-MMP; MT2MMP; MTMMP2; SMCP-2
UniProt ID: (Human) P51511
Entrez Gene ID: (Human) 4324